Progesterone induces meiosis through two obligate co-receptors with PLA2 activity
| Title: | Progesterone induces meiosis through two obligate co-receptors with PLA2 activity |
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| Authors: | Nancy Nader, Lama Assaf, Lubna Zarif, Anna Halama, Sharan Yadav, Maya Dib, Nabeel Attarwala, Qiuying Chen, Karsten Suhre, Steven Gross, Khaled Machaca |
| Source: | eLife, Vol 13 (2025) |
| Publisher Information: | eLife Sciences Publications Ltd, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Medicine LCC:Science LCC:Biology (General) |
| Subject Terms: | progesterone, membrane progesterone receptor beta, ABHD2, nongenomic signaling, PLA2, lipid messengers, Medicine, Science, Biology (General), QH301-705.5 |
| More Details: | The steroid hormone progesterone (P4) regulates multiple aspects of reproductive and metabolic physiology. Classical P4 signaling operates through nuclear receptors that regulate transcription. In addition, P4 signals through membrane P4 receptors (mPRs) in a rapid nongenomic modality. Despite the established physiological importance of P4 nongenomic signaling, the details of its signal transduction cascade remain elusive. Here, using Xenopus oocyte maturation as a well-established physiological readout of nongenomic P4 signaling, we identify the lipid hydrolase ABHD2 (α/β hydrolase domain-containing protein 2) as an essential mPRβ co-receptor to trigger meiosis. We show using functional assays coupled to unbiased and targeted cell-based lipidomics that ABHD2 possesses a phospholipase A2 (PLA2) activity that requires mPRβ. This PLA2 activity bifurcates P4 signaling by inducing clathrin-dependent endocytosis of mPRβ, resulting in the production of lipid messengers that are G-protein coupled receptor agonists. Therefore, P4 drives meiosis by inducing an ABHD2 PLA2 activity that requires both mPRβ and ABHD2 as obligate co-receptors. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2050-084X |
| Relation: | https://elifesciences.org/articles/92635; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.92635 |
| Access URL: | https://doaj.org/article/9f06b6c484234e7caab2993e2bf4060d |
| Accession Number: | edsdoj.9f06b6c484234e7caab2993e2bf4060d |
| Database: | Directory of Open Access Journals |
| ISSN: | 2050084X |
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| DOI: | 10.7554/eLife.92635 |
| Published in: | eLife |
| Language: | English |