Is autism driven by epilepsy in infants with Tuberous Sclerosis Complex?
| Title: | Is autism driven by epilepsy in infants with Tuberous Sclerosis Complex? |
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| Authors: | Romina Moavero, Katarzyna Kotulska, Lieven Lagae, Arianna Benvenuto, Leonardo Emberti Gialloreti, Bernhard Weschke, Kate Riney, Martha Feucht, Pavel Krsek, Rima Nabbout, Anna C. Jansen, Konrad Wojdan, Julita Borkowska, Krzysztof Sadowski, Christoph Hertzberg, Monique M. Van Schooneveld, Sharon Samueli, Alice Maulisovà, Eleonora Aronica, David J. Kwiatkowski, Floor E. Jansen, Sergiusz Jozwiak, Paolo Curatolo, the EPISTOP Consortium |
| Source: | Annals of Clinical and Translational Neurology, Vol 7, Iss 8, Pp 1371-1381 (2020) |
| Publisher Information: | Wiley, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry LCC:Neurology. Diseases of the nervous system |
| Subject Terms: | Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: | Abstract Objective To evaluate the relationship between age at seizure onset and neurodevelopmental outcome at age 24 months in infants with TSC, as well as the effect on neurodevelopmental outcome of early versus conventional treatment of epileptic seizures with vigabatrin (80–150 mg/kg/day). Methods Infants with TSC, aged ≤4 months and without previous seizures were enrolled in a prospective study and closely followed with monthly video EEG and serial standardized neurodevelopmental testing (Bayley Scales of Infant Development and Autism Diagnostic Observation Schedule). Results Eighty infants were enrolled. At the age of 24 months testing identified risk of Autism Spectrum Disorder (ASD) in 24/80 children (30.0%), and developmental delay (DD) in 26/80 (32.5%). Children with epilepsy (51/80; 63.8%) had a higher risk of ASD (P = 0.02) and DD (P = 0.001). Overall, no child presented with moderate or severe DD at 24 months (developmental quotient |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2328-9503 65289943 |
| Relation: | https://doaj.org/toc/2328-9503 |
| DOI: | 10.1002/acn3.51128 |
| Access URL: | https://doaj.org/article/9ee0ecd1135c49efbd34863b65289943 |
| Accession Number: | edsdoj.9ee0ecd1135c49efbd34863b65289943 |
| Database: | Directory of Open Access Journals |
| ISSN: | 23289503 65289943 |
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| DOI: | 10.1002/acn3.51128 |
| Published in: | Annals of Clinical and Translational Neurology |
| Language: | English |