Bibliographic Details
| Title: |
Membrane dual-targeting probes: A promising strategy for fluorescence-guided prostate cancer surgery and lymph node metastases detection |
| Authors: |
Ling-Ling Wu, Qinxin Zhao, Qinghua Wang, Qingyang Zhang, Feiya Yang, Bo Zheng, Hai-Yu Hu, Nianzeng Xing |
| Source: |
Acta Pharmaceutica Sinica B, Vol 13, Iss 3, Pp 1204-1215 (2023) |
| Publisher Information: |
Elsevier, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Therapeutics. Pharmacology |
| Subject Terms: |
Activated probe, Small molecule nanoparticle, Self-assembly, Dual-targeting, Near-infrared, Prostate cancer, Therapeutics. Pharmacology, RM1-950 |
| More Details: |
Fluorescence-guided surgery (FGS) with tumor-targeted imaging agents, particularly those using the near-infrared wavelength, has emerged as a real-time technique to highlight the tumor location and margins during a surgical procedure. For accurate visualization of prostate cancer (PCa) boundary and lymphatic metastasis, we developed a new approach involving an efficient self-quenched near-infrared fluorescence probe, Cy-KUE-OA, with dual PCa-membrane affinity. Cy-KUE-OA specifically targeted the prostate-specific membrane antigen (PSMA), anchored into the phospholipids of the cell membrane of PCa cells and consequently showed a strong Cy7-de-quenching effect. This dual–membrane-targeting probe allowed us to detect PSMA-expressing PCa cells both in vitro and in vivo and enabled clear visualization of the tumor boundary during fluorescence-guided laparoscopic surgery in PCa mouse models. Furthermore, the high PCa preference of Cy-KUE-OA was confirmed on surgically resected patient specimens of healthy tissues, PCa, and lymph node metastases. Taken together, our results serve as a bridge between preclinical and clinical research in FGS of PCa and lay a solid foundation for further clinical research. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2211-3835 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2211383522003318; https://doaj.org/toc/2211-3835 |
| DOI: |
10.1016/j.apsb.2022.07.018 |
| Access URL: |
https://doaj.org/article/9ecebdec33bf4a549c9742bf48fcc2b7 |
| Accession Number: |
edsdoj.9ecebdec33bf4a549c9742bf48fcc2b7 |
| Database: |
Directory of Open Access Journals |
