Bibliographic Details
| Title: |
Role of Epstein-Barr Virus and Human Papillomavirus Coinfection in Cervical Cancer: Epidemiology, Mechanisms and Perspectives |
| Authors: |
Rancés Blanco, Diego Carrillo-Beltrán, Julio C. Osorio, Gloria M Calaf, Francisco Aguayo |
| Source: |
Pathogens, Vol 9, Iss 9, p 685 (2020) |
| Publisher Information: |
MDPI AG, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
Epstein-Barr virus, human papillomavirus, coinfection, cervical cancer, tissue-infiltrating lymphocytes, Medicine |
| More Details: |
High-risk human papillomavirus (HR-HPV) is etiologically associated with the development and progression of cervical cancer, although other factors are involved. Epstein-Barr virus (EBV) detection in premalignant and malignant tissues from uterine cervix has been widely reported; however, its contribution to cervical cancer development is still unclear. Here, a comprehensive analysis regarding EBV presence and its potential role in cervical cancer, the frequency of EBV/HR-HPV coinfection in uterine cervix and EBV infection in tissue-infiltrating lymphocytes were revised. Overall, reports suggest a potential link of EBV to the development of cervical carcinomas in two possible pathways: (1) Infecting epithelial cells, thus synergizing with HR-HPV (direct pathway), and/or (2) infecting tissue-infiltrating lymphocytes that could generate local immunosuppression (indirect pathway). In situ hybridization (ISH) and/or immunohistochemical methods are mandatory for discriminating the cell type infected by EBV. However, further studies are needed for a better understanding of the EBV/HR-HPV coinfection role in cervical carcinogenesis. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2076-0817 |
| Relation: |
https://www.mdpi.com/2076-0817/9/9/685; https://doaj.org/toc/2076-0817 |
| DOI: |
10.3390/pathogens9090685 |
| Access URL: |
https://doaj.org/article/9ea73cfa638d46f8ba9a0ce6fe208494 |
| Accession Number: |
edsdoj.9ea73cfa638d46f8ba9a0ce6fe208494 |
| Database: |
Directory of Open Access Journals |
