Bibliographic Details
| Title: |
The relationship between perihematomal edema and hematoma expansion in acute spontaneous intracerebral hemorrhage: an exploratory radiomics analysis study |
| Authors: |
Zhiming Zhou, Xiaojia Wu, Yuanyuan Chen, Yuanxin Tan, Yu Zhou, Tianxing Huang, Hongli Zhou, Qi Lai, Dajing Guo |
| Source: |
Frontiers in Neuroscience, Vol 18 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
Radiomics, computed tomography, perihematomal edema, intracerebral hemorrhage, hematoma expansion, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
BackgroundThe relationship between early perihematomal edema (PHE) and hematoma expansion (HE) is unclear. We investigated this relationship in patients with acute spontaneous intracerebral hemorrhage (ICH), using radiomics.MethodsIn this multicenter retrospective study, we analyzed 490 patients with spontaneous ICH who underwent non-contrast computed tomography within 6 h of symptom onset, with follow-up imaging at 24 h. We performed HE and PHE image segmentation, and feature extraction and selection to identify HE-associated optimal radiomics features. We calculated radiomics scores of hematoma (Radscores_HEA) and PHE (Radscores_PHE) and constructed a combined model (Radscore_HEA_PHE). Relationships of the PHE radiomics features or Radscores_PHE with clinical variables, hematoma imaging signs, Radscores_HEA, and HE were assessed by univariate, correlation, and multivariate analyses. We compared predictive performances in the training (n = 296) and validation (n = 194) cohorts.ResultsShape_VoxelVolume and Shape_MinorAxisLength of PHE were identified as optimal radiomics features associated with HE. Radscore_PHE (odds ratio = 1.039, p = 0.032) was an independent HE risk factor after adjusting for the ICH onset time, Glasgow Coma Scale score, baseline hematoma volume, hematoma shape, hematoma density, midline shift, and Radscore_HEA. The areas under the receiver operating characteristic curve of Radscore_PHE in the training and validation cohorts were 0.808 and 0.739, respectively. After incorporating Radscore_PHE, the integrated discrimination improvements of Radscore_HEA_PHE in the training and validation cohorts were 0.009 (p = 0.086) and −0.011 (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1662-453X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fnins.2024.1394795/full; https://doaj.org/toc/1662-453X |
| DOI: |
10.3389/fnins.2024.1394795 |
| Access URL: |
https://doaj.org/article/cec9e72fa29a4e1f8f0dc836ba0cb35c |
| Accession Number: |
edsdoj.9e72fa29a4e1f8f0dc836ba0cb35c |
| Database: |
Directory of Open Access Journals |
