Academic Journal
View in EDS
PDF Full Text

Spotlight on PSMA as a new theranostic biomarker for bladder cancer

Bibliographic Details
Title: Spotlight on PSMA as a new theranostic biomarker for bladder cancer
Authors: Maria Maddalena Tumedei, Sara Ravaioli, Federica Matteucci, Monica Celli, Ugo De Giorgi, Roberta Gunelli, Maurizio Puccetti, Giovanni Paganelli, Sara Bravaccini
Source: Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Publisher Information: Nature Portfolio, 2021.
Publication Year: 2021
Collection: LCC:Medicine
LCC:Science
Subject Terms: Medicine, Science
More Details: Abstract Bladder cancer (BCa) patients are diagnosed by cytology and cystoscopy. However, these diagnostic tests bear some limitations. We sought for reliable biomarkers to better determine BCa extension. Prostate-specific membrane antigen (PSMA) appears to fulfill this requirement in prostate cancer but its role in BCa has not been established yet. We then analyzed 87 bladder tissue samples from 74 patients assessing PSMA expression by immunohistochemistry. The median PSMA expression, exclusively found in tumor neovasculature, in terms of H-score significantly differed between non-tumor samples and tumor samples (p = 0.00288) showing a higher neovasculature-related PSMA expression. No differences were observed in relation to tumor type, grade and stage. BCa neovasculature-related PSMA overexpression may be useful in defining the degree of extension of the neoplasm. In addition, testing PSMA expression by immunohistochemistry may hold theranostic implications both considering anti-angiogenesis agents and radio-labelled PSMA ligands for intracavitary radionuclide therapy. In our opinion, BCa neovasculature-related PSMA overexpression may be considered an apt target for anti-angiogenesis and radionuclide treatment in BCa, once the evaluation of tumor-retention time for the appropriateness of long half-life therapeutic PSMA ligands as radionuclide treatment will be performed.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-021-89160-0
Access URL: https://doaj.org/article/9e48e4bb4424421c8efc0070bd91a8d6
Accession Number: edsdoj.9e48e4bb4424421c8efc0070bd91a8d6
Database: Directory of Open Access Journals
FullText Links:
  – Type: pdflink
    Url: https://content.ebscohost.com/cds/retrieve?content=AQICAHjPtM4BHU3ZchRwgzYmadcigk49r9CVlbU7V5F6lgH7WwE_0f93OE1NlUdxHY4of6DTAAAA4TCB3gYJKoZIhvcNAQcGoIHQMIHNAgEAMIHHBgkqhkiG9w0BBwEwHgYJYIZIAWUDBAEuMBEEDIc7PdZQS-W2iW_HWwIBEICBmU35xgQ_aEUtvxaljIOtbFY3QMra_SmjPwGgocLOcnGTd52Qlx4wytKXUT-ZtNxD841gtFWkTQzoTg0QaQAHoHGcfedAC0gWJqGex3MMCxBHjzuDnelO1Ct8HIr12cfDDr0Qx0XcbnJyGL53hhIN5rqGmdrW0RM-gDtWvSshvQKNbOav1Kpcl2RZJUrE2GXiyCFhN5RJN28axw==
Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=20452322&ISBN=&volume=11&issue=1&date=20210501&spage=1&pages=1-7&title=Scientific Reports&atitle=Spotlight%20on%20PSMA%20as%20a%20new%20theranostic%20biomarker%20for%20bladder%20cancer&aulast=Maria%20Maddalena%20Tumedei&id=DOI:10.1038/s41598-021-89160-0
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
  – Url: https://doaj.org/article/9e48e4bb4424421c8efc0070bd91a8d6
    Name: EDS - DOAJ (s8985755)
    Category: fullText
    Text: View record from DOAJ
    MouseOverText: View record from DOAJ
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.9e48e4bb4424421c8efc0070bd91a8d6
RelevancyScore: 949
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 948.723937988281
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Spotlight on PSMA as a new theranostic biomarker for bladder cancer
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Maria+Maddalena+Tumedei%22">Maria Maddalena Tumedei</searchLink><br /><searchLink fieldCode="AR" term="%22Sara+Ravaioli%22">Sara Ravaioli</searchLink><br /><searchLink fieldCode="AR" term="%22Federica+Matteucci%22">Federica Matteucci</searchLink><br /><searchLink fieldCode="AR" term="%22Monica+Celli%22">Monica Celli</searchLink><br /><searchLink fieldCode="AR" term="%22Ugo+De+Giorgi%22">Ugo De Giorgi</searchLink><br /><searchLink fieldCode="AR" term="%22Roberta+Gunelli%22">Roberta Gunelli</searchLink><br /><searchLink fieldCode="AR" term="%22Maurizio+Puccetti%22">Maurizio Puccetti</searchLink><br /><searchLink fieldCode="AR" term="%22Giovanni+Paganelli%22">Giovanni Paganelli</searchLink><br /><searchLink fieldCode="AR" term="%22Sara+Bravaccini%22">Sara Bravaccini</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Nature Portfolio, 2021.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2021
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Medicine<br />LCC:Science
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Science%22">Science</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Abstract Bladder cancer (BCa) patients are diagnosed by cytology and cystoscopy. However, these diagnostic tests bear some limitations. We sought for reliable biomarkers to better determine BCa extension. Prostate-specific membrane antigen (PSMA) appears to fulfill this requirement in prostate cancer but its role in BCa has not been established yet. We then analyzed 87 bladder tissue samples from 74 patients assessing PSMA expression by immunohistochemistry. The median PSMA expression, exclusively found in tumor neovasculature, in terms of H-score significantly differed between non-tumor samples and tumor samples (p = 0.00288) showing a higher neovasculature-related PSMA expression. No differences were observed in relation to tumor type, grade and stage. BCa neovasculature-related PSMA overexpression may be useful in defining the degree of extension of the neoplasm. In addition, testing PSMA expression by immunohistochemistry may hold theranostic implications both considering anti-angiogenesis agents and radio-labelled PSMA ligands for intracavitary radionuclide therapy. In our opinion, BCa neovasculature-related PSMA overexpression may be considered an apt target for anti-angiogenesis and radionuclide treatment in BCa, once the evaluation of tumor-retention time for the appropriateness of long half-life therapeutic PSMA ligands as radionuclide treatment will be performed.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 2045-2322
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: https://doaj.org/toc/2045-2322
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1038/s41598-021-89160-0
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/9e48e4bb4424421c8efc0070bd91a8d6" linkWindow="_blank">https://doaj.org/article/9e48e4bb4424421c8efc0070bd91a8d6</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.9e48e4bb4424421c8efc0070bd91a8d6
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.9e48e4bb4424421c8efc0070bd91a8d6
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41598-021-89160-0
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 1
    Subjects:
      – SubjectFull: Medicine
        Type: general
      – SubjectFull: Science
        Type: general
    Titles:
      – TitleFull: Spotlight on PSMA as a new theranostic biomarker for bladder cancer
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Maria Maddalena Tumedei
      – PersonEntity:
          Name:
            NameFull: Sara Ravaioli
      – PersonEntity:
          Name:
            NameFull: Federica Matteucci
      – PersonEntity:
          Name:
            NameFull: Monica Celli
      – PersonEntity:
          Name:
            NameFull: Ugo De Giorgi
      – PersonEntity:
          Name:
            NameFull: Roberta Gunelli
      – PersonEntity:
          Name:
            NameFull: Maurizio Puccetti
      – PersonEntity:
          Name:
            NameFull: Giovanni Paganelli
      – PersonEntity:
          Name:
            NameFull: Sara Bravaccini
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-print
              Value: 20452322
          Numbering:
            – Type: volume
              Value: 11
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Scientific Reports
              Type: main
ResultId 1