Academic Journal
Recent updates of centromere proteins in hepatocellular carcinoma: a review
| Title: | Recent updates of centromere proteins in hepatocellular carcinoma: a review |
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| Authors: | Zhongyuan Yang, Wenjiao Chen, Yunhui Liu, Yuxin Niu |
| Source: | Infectious Agents and Cancer, Vol 20, Iss 1, Pp 1-12 (2025) |
| Publisher Information: | BMC, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Infectious and parasitic diseases |
| Subject Terms: | Hepatocellular carcinoma, Centromere protein, Chromosomal instability, Therapeutic target, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Infectious and parasitic diseases, RC109-216 |
| More Details: | Abstract Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death worldwide, with approximately 800,000 deaths worldwide each year. Owing to the atypical early symptoms and characteristics of HCC, over 80% of HCC patients cannot receive curative treatment. The treatment of HCC is facing a bottleneck, and new treatment methods are urgently needed. Since the pathogenesis of HCC is not yet clear, identifying the molecular mechanisms and therapeutic targets related to it is crucial. Centromeres are considered special deoxyribonucleic acid (DNA) sequences with highly repetitive sequences that are physically connected to the spindle during cell division, ensuring equal division of genetic material between daughter cells. The numerous proteins that aggregate on this sequence during cell division are called centromere proteins (CENPs). Currently, numerous studies have shown that CENPs are abnormally expressed in tumor cells and are associated with patient prognosis. The abnormal expression of CENPs is a key cause of chromosomal instability. Furthermore, chromosomal instability is a common characteristic of the majority of tumors. Chromosomal instability can lead to uncontrolled and sustained division and proliferation of malignant tumors. Therapeutic plans targeting CENPs play important roles in the treatment of HCC. For example, small ribonucleic acid (RNA) can silence CENP expression and prevent the occurrence and development of liver cancer. In recent years, studies of HCC-targeting CENPs have gradually increased but are still relatively novel, requiring further systematic elaboration. In this review, we provide a detailed introduction to the characteristics of CENPs and discuss their roles in HCC. In addition, we discuss their application prospects in future clinical practice. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1750-9378 |
| Relation: | https://doaj.org/toc/1750-9378 |
| DOI: | 10.1186/s13027-024-00630-2 |
| Access URL: | https://doaj.org/article/9e2dcfeca61f4f11b9a87b054976fd62 |
| Accession Number: | edsdoj.9e2dcfeca61f4f11b9a87b054976fd62 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 17509378 |
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| DOI: | 10.1186/s13027-024-00630-2 |
| Published in: | Infectious Agents and Cancer |
| Language: | English |