Bibliographic Details
| Title: |
High baseline expression of IL-6 and IL-10 decreased CCR7 B cells in individuals with previous SARS-CoV-2 infection during BNT162b2 vaccination |
| Authors: |
Alberto Ponciano-Gómez, Martha Iris Valle-Solis, Myriam Campos-Aguilar, Rafael Jijón-Lorenzo, Elena de la C. Herrera-Cogco, Roberto Ramos-Alor, César Isaac Bazán-Mendez, Gustavo Antonio Pérez-Gil Cervantes, Ricardo Ávila-García, Abdiel González Aguilar, Moises Geovani Salmerón Texale, Wilfrido David Tapia-Sánchez, Carlos Leonardo Duarte-Martínez, Sandra Olivas-Quintero, Santiago Cristobal Sigrist-Flores, Itzell Alejandrina Gallardo-Ortíz, Rafael Villalobos-Molina, Adolfo Rene Méndez-Cruz, Rafael Jimenez-Flores, Leopoldo Santos-Argumedo, Juan Pedro Luna-Arias, Hector Romero-Ramírez, Victor Hugo Rosales-García, Bartolo Avendaño-Borromeo |
| Source: |
Frontiers in Immunology, Vol 13 (2022) |
| Publisher Information: |
Frontiers Media S.A., 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
SARS-CoV-2, BNT162b2, Interleukin 6, Interleukin 10, CCR7 B cells, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
The current pandemic generated by SARS-CoV-2 has led to mass vaccination with different biologics that have shown wide variations among human populations according to the origin and formulation of the vaccine. Studies evaluating the response in individuals with a natural infection before vaccination have been limited to antibody titer analysis and evaluating a few humoral and cellular response markers, showing a more rapid and intense humoral response than individuals without prior infection. However, the basis of these differences has not been explored in depth. In the present work, we analyzed a group of pro and anti-inflammatory cytokines, antibody titers, and cell populations in peripheral blood of individuals with previous SARS-CoV-2 infection using BNT162b2 biologic. Our results suggest that higher antibody concentration in individuals with an earlier disease could be generated by higher production of plasma cells to the detriment of the presence of memory B cells in the bloodstream, which could be related to the high baseline expression of cytokines (IL-6 and IL-10) before vaccination. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2022.946770/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2022.946770 |
| Access URL: |
https://doaj.org/article/9de834a23e8b470ebe5dd071217e9be3 |
| Accession Number: |
edsdoj.9de834a23e8b470ebe5dd071217e9be3 |
| Database: |
Directory of Open Access Journals |
