Bibliographic Details
| Title: |
Investigation of the correlation between AGRN expression and perineural invasion in colon cancer |
| Authors: |
Lei Chen, Haijia Zhang, Kaiyue Gao, Fanqi Meng, Funing Yang, Jiannan Li, Lijie Wang, Jiandong Tai |
| Source: |
Frontiers in Molecular Biosciences, Vol 11 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
colon cancer, perineural invasion, AGRN, bioinformatics, immunohistochemistry, Biology (General), QH301-705.5 |
| More Details: |
Background and PurposeColon cancer is one of the most common gastrointestinal malignancies. According to the traditional view, the primary modes of transmission include direct dissemination, hematogenous metastasis, and lymph node metastasis. In recent years, the role of perineural invasion (PNI) in the spread and metastasis of tumors has received immense attention. However, there are still relatively few reports on the potential mechanisms and biomarkers of PNI occurrence and development in colon cancer.MethodWe identified genes linked to the onset and progression of PNI in colon cancer using bioinformatics tools and extensive databases. Gene function enrichment analysis was used to explore the potential roles of these genes in tumor proliferation, invasion, and PNI. A collection of postoperative pathological specimens from colon cancer patients who underwent surgery, related clinicopathological data, and immunohistochemistry were used to validate AGRN expression in PNI tissues.ResultsBioinformatics analysis revealed that AGRN is overexpressed in colon cancer tissues and correlates with poor patient prognosis. The findings from gene association and enrichment studies indicate that AGRN and its associated genes may play a role in PNI development and progression in colon cancer by simultaneously enhancing tumor cell invasion and neural cell growth. Immunohistochemical analysis of clinical samples confirmed that AGRN expression is elevated in colon cancer tissues with PNI.ConclusionWe found that AGRN is significantly overexpressed in colon cancer tissues exhibiting PNI and is linked to poor patient survival. AGRN and its related genes may contribute to PNI by promoting tumor cell invasion and neural cell growth. Hence, AGRN may play a crucial role in the initiation and progression of PNI in colon cancer. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2296-889X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fmolb.2024.1510478/full; https://doaj.org/toc/2296-889X |
| DOI: |
10.3389/fmolb.2024.1510478 |
| Access URL: |
https://doaj.org/article/9dabc87c279b4a1281b75b4e05448e24 |
| Accession Number: |
edsdoj.9dabc87c279b4a1281b75b4e05448e24 |
| Database: |
Directory of Open Access Journals |
