Bibliographic Details
| Title: |
Risk factors for very low-level viremia in patients with chronic hepatitis B virus infection: A single-center retrospective study |
| Authors: |
Jiahui Lu, Congnan Zhang, Pengyuan He, Mengdang Ou, Jinyu Xia, Mingxing Huang |
| Source: |
Liver Research, Vol 6, Iss 1, Pp 39-44 (2022) |
| Publisher Information: |
KeAi Communications Co., Ltd., 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Diseases of the digestive system. Gastroenterology |
| Subject Terms: |
Hepatitis B virus (HBV), Chronic hepatitis B (CHB), Very low-level viremia (VLLV), Risk factors, Diseases of the digestive system. Gastroenterology, RC799-869 |
| More Details: |
Background and aim: Several effective antiviral drugs are now available; however, the risk of liver-related complications is still present. Low-level viremia (LLV), defined as a hepatitis B virus (HBV) deoxyribonucleic acid (DNA) load lower than 2000 IU/mL, is one of the major factors responsible for these complications. It has been reported that 22.7–43.1% of patients with HBV experience LLV. Herein, we aimed to explore the risk factors for very LLV (VLLV) during antiviral treatment. Methods: We collected data of patients with chronic hepatitis B (CHB) who received nucleos(t)ide analog treatment from October 2016 to April 2021. VLLV was defined as an HBV DNA load of 9–20 IU/mL. A total of 139 patients with LLV were matched with 139 patients with a sustained virological response at a 1:1 ratio according to age and gender. Results: Seropositivity rates for hepatitis B e antigen (HBeAg) (45.3% vs. 17.3%, P 0.050). HBeAg seropositivity (aOR, 5.08; 95% CI: 2.15–12.02; P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2542-5684 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2542568422000046; https://doaj.org/toc/2542-5684 |
| DOI: |
10.1016/j.livres.2022.02.001 |
| Access URL: |
https://doaj.org/article/d9d9837dee7643d292e5ab64d8fa67e3 |
| Accession Number: |
edsdoj.9d9837dee7643d292e5ab64d8fa67e3 |
| Database: |
Directory of Open Access Journals |
