Bibliographic Details
| Title: |
Prevalence of Mpox vaccine acceptance and hesitancy among people living with HIV: a comprehensive systematic review and meta-analysis |
| Authors: |
Ambanna Yappalparvi, Mahalaqua Nazli Khatib, Ashok Kumar Balaraman, M. M. Rekha, Mandeep Kaur, Girish Chandra Sharma, Puneet Sudan, K. Satyam Naidu, Rajesh Singh, Sonam Ramashankar, Karan Khati, Sanjay Singh Chauhan, Lokesh Verma, Amritpal Sidhu, Rachana Mehta, Renu Sah, Abhay M. Gaidhane, Muhammed Shabil, Joseph Clement Chipeta, Ganesh Bushi |
| Source: |
AIDS Research and Therapy, Vol 22, Iss 1, Pp 1-10 (2025) |
| Publisher Information: |
BMC, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
Immunologic diseases. Allergy, RC581-607 |
| More Details: |
Abstract Background Vaccine acceptance among People Living with HIV (PLWH) is crucial for managing and mitigating the spread of infectious diseases, including Mpox. This systematic review and meta-analysis assess the rate of vaccine acceptance for Mpox among PLWH and identify factors influencing these rates. Methods We searched major databases including PubMed, Embase, and Web of Science up to 30 August 2024 for observational studies involving PLWH that reported on mpox vaccine acceptance rates. A random-effects model was employed for the meta-analysis, utilizing R software version 4.4. Heterogeneity among the studies was quantified using the I² statistic, and the methodological quality of each study was assessed using a modified version of the Newcastle-Ottawa Scale. Results Out of 1,123 articles identified, 17 studies met the inclusion criteria and included 7,248 participants. The pooled estimate of the Mpox vaccine acceptance rate was 61.1% (95% CI: 44.2-75.7%), with high heterogeneity (I² = 99%). Additionally, a pooled vaccine hesitancy prevalence was 13.2%, (95% CI: 2.4-48.6%), reflecting substantial variability and had high heterogeneity (I² = 98%). Conclusion This systematic review and meta-analysis reveal moderate Mpox vaccine acceptance and considerable hesitancy among PLWH. To further increase vaccine uptake and address any remaining hesitancy in this at-risk population, targeted public health strategies and ongoing research are necessary. Strengthening vaccine acceptance is critical to safeguarding PLWH against emerging infectious diseases such as Mpox. Clinical Trial Number Not applicable. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1742-6405 |
| Relation: |
https://doaj.org/toc/1742-6405 |
| DOI: |
10.1186/s12981-025-00726-8 |
| Access URL: |
https://doaj.org/article/a9d957dc4f29436da996df71c3762e0e |
| Accession Number: |
edsdoj.9d957dc4f29436da996df71c3762e0e |
| Database: |
Directory of Open Access Journals |
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