Academic Journal
Research development on gut microbiota and vulnerable atherosclerotic plaque
| Title: | Research development on gut microbiota and vulnerable atherosclerotic plaque |
|---|---|
| Authors: | Shujiao Zheng, Zuheng Liu, Haiyue Liu, Jie Ying Lim, Dolly Wong Hui Li, Shaofeng Zhang, Fang Luo, Xiujing Wang, Changqing Sun, Rong Tang, Wuyang Zheng, Qiang Xie |
| Source: | Heliyon, Vol 10, Iss 4, Pp e25186- (2024) |
| Publisher Information: | Elsevier, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Science (General) LCC:Social sciences (General) |
| Subject Terms: | Atherosclerosis, Gut microbiota, Bacterial metabolites, Vulnerable plaque, Acute coronary syndrome, Science (General), Q1-390, Social sciences (General), H1-99 |
| More Details: | The relationship between gut microbiota and its metabolites with cardiovascular disease (CVD) has been proven. In this review, we aim to conclude the potential mechanism of gut microbiota and its metabolites on inducing the formation of vulnerable atherosclerotic plaque, and to discuss the effect of intestinal metabolites, including trimethylamine-N-oxide (TMAO), lipopolysaccharide (LPS), phenylacetylglutamine (PAG), short-chain fatty acids (SCFAs) on plaque stability. Finally, we include the impact of gut microbiota and its metabolites on plaque stability, to propose a new therapeutic direction for coronary heart disease. Gut microbiota regulation intervenes the progress of arteriosclerosis, especially on coronary atherosclerosis, by avoiding or reducing the formation of vulnerable plaque, to lower the morbidity rate of myocardial infarction. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844024012179; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2024.e25186 |
| Access URL: | https://doaj.org/article/9d7ae91e5e634e70be925da9dcbc9ae7 |
| Accession Number: | edsdoj.9d7ae91e5e634e70be925da9dcbc9ae7 |
| Database: | Directory of Open Access Journals |
| ISSN: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2024.e25186 |
| Published in: | Heliyon |
| Language: | English |