Endothelin-1 gene and endothelin receptor A gene polymorphisms in severe pulmonary hypertension associated with rheumatic mitral valve disease
| Title: | Endothelin-1 gene and endothelin receptor A gene polymorphisms in severe pulmonary hypertension associated with rheumatic mitral valve disease |
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| Authors: | Pratishtha Mehra, Vimal Mehta, Jamal Yusuf, Rishi Sukhija, Wilbert S. Aronow |
| Source: | Archives of Medical Science, Vol 18, Iss 1, Pp 260-266 (2022) |
| Publisher Information: | Termedia Publishing House, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Medicine |
| Subject Terms: | pulmonary hypertension, mitral stenosis, rheumatic heart disease, endothelin-1 gene polymorphism, Medicine |
| More Details: | Introduction Endothelin-1 (ET-1) gene polymorphisms are implicated in pathogenesis of idiopathic pulmonary arterial hypertension Material and methods We studied ET-1 (Lys198Asn and 3A/4A) and endothelin receptor A (ETA) gene (His323His) polymorphisms in 123 subjects with pulmonary hypertension associated with rheumatic mitral valve disease (PH-MVD) and 123 healthy controls. Results The mutant homozygous Asn/Asn genotype in Lys198Asn and T/T genotype in His323His polymorphism was more prevalent in PH-MVD group. Presence of Asn/Asn genotype was significantly associated with increased risk (odds ratio 3.9). Conclusions ET-1 and ET A gene polymorphisms are prevalent in PH-MVD group suggesting that they may predispose to the development of PH. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1734-1922 1896-9151 |
| Relation: | https://www.archivesofmedicalscience.com/Endothelin-1-gene-and-endothelin-receptor-A-gene-polymorphisms-in-severe-pulmonary,144630,0,2.html; https://doaj.org/toc/1734-1922; https://doaj.org/toc/1896-9151 |
| DOI: | 10.5114/aoms/144630 |
| Access URL: | https://doaj.org/article/9d473e166a48406ab7741e02e7cb269e |
| Accession Number: | edsdoj.9d473e166a48406ab7741e02e7cb269e |
| Database: | Directory of Open Access Journals |
| ISSN: | 17341922 18969151 |
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| DOI: | 10.5114/aoms/144630 |
| Published in: | Archives of Medical Science |
| Language: | English |