Chemoradiotherapy‐induced increase in Th17 cell frequency in cervical cancer patients is associated with therapy resistance and early relapse
| Title: | Chemoradiotherapy‐induced increase in Th17 cell frequency in cervical cancer patients is associated with therapy resistance and early relapse |
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| Authors: | Laura Theobald, Russalina Stroeder, Patrick Melchior, Ioan Iulian Iordache, Tanja Tänzer, Meike Port, Birgit Glombitza, Stefanie Marx, David Schub, Christian Herr, Martin Hart, Nicole Ludwig, Eckart Meese, Yoo‐Jin Kim, Rainer Maria Bohle, Sigrun Smola, Christian Rübe, Erich Franz Solomayer, Barbara Walch‐Rückheim |
| Source: | Molecular Oncology, Vol 15, Iss 12, Pp 3559-3577 (2021) |
| Publisher Information: | Wiley, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | AKT, cervical cancer recurrence, chemoradiotherapy, resistance, T‐helper‐17 cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Cervical cancer therapy is still a major clinical challenge, as patients substantially differ in their response to standard treatments, including chemoradiotherapy (CRT). During cervical carcinogenesis, T‐helper (Th)‐17 cells accumulate in the peripheral blood and tumor tissues of cancer patients and are associated with poor prognosis. In this prospective study, we find increased Th17 frequencies in the blood of patients after chemoradiotherapy and a post‐therapeutic ratio of Th17/CD4+ T cells > 8% was associated with early recurrence. Furthermore, Th17 cells promote resistance of cervical cancer cells toward CRT, which was dependent on the AKT signaling pathway. Consistently, patients with high Th17 frequencies in pretherapeutic biopsies exhibit lower response to primary CRT. This work reveals a key role of Th17 cells in CRT resistance and elevated Th17 frequencies in the blood after CRT correspond with early recurrence. Our results may help to explain individual treatment responses of cervical cancer patients and suggest evaluation of Th17 cells as a novel predictive biomarker for chemoradiotherapy responses and as a potential target for immunotherapy in cervical cancer. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1878-0261 1574-7891 |
| Relation: | https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261 |
| DOI: | 10.1002/1878-0261.13095 |
| Access URL: | https://doaj.org/article/9d39a3e2e8984294abe5e69d7e568744 |
| Accession Number: | edsdoj.9d39a3e2e8984294abe5e69d7e568744 |
| Database: | Directory of Open Access Journals |
| ISSN: | 18780261 15747891 |
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| DOI: | 10.1002/1878-0261.13095 |
| Published in: | Molecular Oncology |
| Language: | English |