Bibliographic Details
| Title: |
Hsa‐circ‐0052001 promotes gastric cancer cell proliferation and invasion via the MAPK pathway |
| Authors: |
Qixuan Xu, Yizhou Yao, Haishun Ni, Jinrong Gu, Xuchao Wang, Linhua Jiang, Bin Wang, Xinguo Zhu |
| Source: |
Cancer Medicine, Vol 12, Iss 6, Pp 7246-7257 (2023) |
| Publisher Information: |
Wiley, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
circRNA, gastric cancer, hsa‐circ‐0052001, MAPK, miR‐608, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Abstract Background Gastric cancer (GC) ranks fourth among the causes of death from malignant tumors in the world. Studies have implicated the dysregulation of circRNAs with GC. However, the relationship between hsa‐circ‐0052001 and GC is unclear. Methods In our current study, we assessed the expression levels of hsa‐circ‐0052001 in GC cells and tissues using quantitative real‐time PCR (qPCR). The role of hsa‐circ‐0052001 expression on the proliferation and invasion of GC cells was assessed using in vitro experiments. The role of hsa‐circ‐0052001 on the proliferation of GC cells was also analyzed using in vivo models. The pathways downstream of hsa‐circ‐0052001 were identified using bioinformatics analyses, western blot (WB) assays, and qRT‐PCR. Results We found that compared with normal gastric mucosa epithelial cells and adjacent paracancer tissues, hsa‐circ‐0052001 was overexpressed in GC cells and tissues. Also, the hsa‐circ‐0052001 level was linked to patient clinicopathological characteristics of GC. Cell proliferation and metastatic ability were inhibited in gastric cancer cells when hsa‐circ‐0052001 was knocked down in vitro and cancer growth in vivo. Mechanistically, hsa‐circ‐0052001 promoted the carcinogenesis of GC cells via the MAPK signal pathway. Conclusion Hsa‐circ‐0052001 functions as a tumor gene in promoting the progression of GC through MAPK pathway, which has provided a promising target for patients with GC. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2045-7634 |
| Relation: |
https://doaj.org/toc/2045-7634 |
| DOI: |
10.1002/cam4.5446 |
| Access URL: |
https://doaj.org/article/ade9d32502fd45a99d838c7c063e9da7 |
| Accession Number: |
edsdoj.9d32502fd45a99d838c7c063e9da7 |
| Database: |
Directory of Open Access Journals |
