Morroniside ameliorates glucocorticoid-induced osteoporosis and promotes osteoblastogenesis by interacting with sodium-glucose cotransporter 2

Bibliographic Details
Title: Morroniside ameliorates glucocorticoid-induced osteoporosis and promotes osteoblastogenesis by interacting with sodium-glucose cotransporter 2
Authors: Hou-Zhi Yang, Runbei Dong, Yutao Jia, Yuqiao Li, Gan Luo, Tianhao Li, Yao Long, Shuang Liang, Shanshan Li, Xin Jin, Tianwei Sun
Source: Pharmaceutical Biology, Vol 61, Iss 1, Pp 416-426 (2023)
Publisher Information: Taylor & Francis Group, 2023.
Publication Year: 2023
Collection: LCC:Therapeutics. Pharmacology
Subject Terms: MC3T3-E1 cells, zebrafish, molecular docking, glucose pockets, SGLT2, Therapeutics. Pharmacology, RM1-950
More Details: AbstractContext Morroniside (MOR) possesses antiosteoporosis (OP) effects, but its molecular target and relevant mechanisms remain unknown.Objective We investigated the effects of MOR on glucocorticoid-induced OP and osteoblastogenesis and its underlying mechanisms.Materials and methods The effects of MOR (10–100 μM) on the proliferation and differentiation of MC3T3-E1 cells were studied in vitro. The glucocorticoid-induced zebrafish OP model was treated with 10, 20 and 40 μM MOR for five days to evaluate its effects on vertebral bone density and related osteogenic markers. In addition, molecular targets prediction and molecular docking analysis were carried out to explore the binding interactions of MOR with the target proteins.Results In cultured MC3T3-E1 cells, 20 μM MOR significantly increased cell viability (1.64 ± 0.12 vs. 0.95 ± 0.16; p
Document Type: article
File Description: electronic resource
Language: English
ISSN: 13880209
1744-5116
1388-0209
Relation: https://doaj.org/toc/1388-0209; https://doaj.org/toc/1744-5116
DOI: 10.1080/13880209.2023.2173787
Access URL: https://doaj.org/article/c9cbfebb18fb4f95a8640b74f9afa3ab
Accession Number: edsdoj.9cbfebb18fb4f95a8640b74f9afa3ab
Database: Directory of Open Access Journals
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More Details
ISSN:13880209
17445116
DOI:10.1080/13880209.2023.2173787
Published in:Pharmaceutical Biology
Language:English