Academic Journal
Morroniside ameliorates glucocorticoid-induced osteoporosis and promotes osteoblastogenesis by interacting with sodium-glucose cotransporter 2
| Title: | Morroniside ameliorates glucocorticoid-induced osteoporosis and promotes osteoblastogenesis by interacting with sodium-glucose cotransporter 2 |
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| Authors: | Hou-Zhi Yang, Runbei Dong, Yutao Jia, Yuqiao Li, Gan Luo, Tianhao Li, Yao Long, Shuang Liang, Shanshan Li, Xin Jin, Tianwei Sun |
| Source: | Pharmaceutical Biology, Vol 61, Iss 1, Pp 416-426 (2023) |
| Publisher Information: | Taylor & Francis Group, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Therapeutics. Pharmacology |
| Subject Terms: | MC3T3-E1 cells, zebrafish, molecular docking, glucose pockets, SGLT2, Therapeutics. Pharmacology, RM1-950 |
| More Details: | AbstractContext Morroniside (MOR) possesses antiosteoporosis (OP) effects, but its molecular target and relevant mechanisms remain unknown.Objective We investigated the effects of MOR on glucocorticoid-induced OP and osteoblastogenesis and its underlying mechanisms.Materials and methods The effects of MOR (10–100 μM) on the proliferation and differentiation of MC3T3-E1 cells were studied in vitro. The glucocorticoid-induced zebrafish OP model was treated with 10, 20 and 40 μM MOR for five days to evaluate its effects on vertebral bone density and related osteogenic markers. In addition, molecular targets prediction and molecular docking analysis were carried out to explore the binding interactions of MOR with the target proteins.Results In cultured MC3T3-E1 cells, 20 μM MOR significantly increased cell viability (1.64 ± 0.12 vs. 0.95 ± 0.16; p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 13880209 1744-5116 1388-0209 |
| Relation: | https://doaj.org/toc/1388-0209; https://doaj.org/toc/1744-5116 |
| DOI: | 10.1080/13880209.2023.2173787 |
| Access URL: | https://doaj.org/article/c9cbfebb18fb4f95a8640b74f9afa3ab |
| Accession Number: | edsdoj.9cbfebb18fb4f95a8640b74f9afa3ab |
| Database: | Directory of Open Access Journals |
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| ISSN: | 13880209 17445116 |
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| DOI: | 10.1080/13880209.2023.2173787 |
| Published in: | Pharmaceutical Biology |
| Language: | English |