Bibliographic Details
| Title: |
PD-L1 Expression Is Associated With VEGFA and LADC Patients' Survival |
| Authors: |
Shaochuan Liu, Tingting Qin, Yanan Jia, Kai Li |
| Source: |
Frontiers in Oncology, Vol 9 (2019) |
| Publisher Information: |
Frontiers Media S.A., 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
PD-L1, VEGFA, overall survival, progression-free survival, lung adenocarcinoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Objectives: To elucidate the relationship between VEGFA and PD-L1 expression in lung adenocarcinoma (LADC).Methods: PD-L1 and VEGFA expression were determined by immunohistochemistry with H-score on formalin-fixed paraffin-embedded resected LADC specimens of 129 cases.Results: High PD-L1 expression in 53 (41.1%) patients, high VEGFA expression in 65 (50.4%), and co-expression in 18 (14.0%) were observed. Inverse correlation between expression of PD-L1 and VEGFA was found (P = 0.002, r = −0.274). VEGFA and PD-L1 expression were not significantly associated with the clinicopathological features. High PD-L1 expression was significantly association with all patients' poor progression-free survival and overall survival in a univariate analysis, but there was no significantly association with high VEGFA expression and prognosis. Co-expression of PD-L1 and VEGFA exhibited a worst overall survival compared to negative groups (P = 0.005).Conclusions: These findings indicate that high PD-L1 expression could impact both poor overall survival and progression-free survival in patients with resected LADC. Co-expression of PD-L1 and VEGFA may be considered as an important prognostic factor for patients with resected lung adenocarcinoma. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2234-943X |
| Relation: |
https://www.frontiersin.org/article/10.3389/fonc.2019.00189/full; https://doaj.org/toc/2234-943X |
| DOI: |
10.3389/fonc.2019.00189 |
| Access URL: |
https://doaj.org/article/d9c823252a2249e4ba599f4ddede8285 |
| Accession Number: |
edsdoj.9c823252a2249e4ba599f4ddede8285 |
| Database: |
Directory of Open Access Journals |
