Bibliographic Details
| Title: |
Long COVID-associated symptoms prevalent in both SARS-CoV-2 positive and negative individuals: A prospective follow-up study |
| Authors: |
Anu Kantele, Juuso Paajanen, Jukka-Pekka Pietilä, Olli Vapalahti, Sari H. Pakkanen, Tinja Lääveri |
| Source: |
New Microbes and New Infections, Vol 56, Iss , Pp 101209- (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Infectious and parasitic diseases |
| Subject Terms: |
SARS-CoV-2, Long covid, Follow-up study, Infectious and parasitic diseases, RC109-216 |
| More Details: |
Background: Research into persistent symptoms among SARS-CoV-2-positive i.e. CoV(+) patients mostly focuses on hospitalized individuals. Our prospective follow-up study compares long COVID-associated symptoms among laboratory-confirmed CoV(+) and SARS-CoV-2 negative [CoV(−)] individuals. Methods: SARS-CoV-2 RT-PCR-tested volunteers were recruited into four cohorts: 1) CoV(+) outpatients, 2) CoV(−) outpatients, 3) CoV(+) intensive care unit (ICU) inpatients, and 4) CoV(+) non-ICU inpatients. Neutralizing antibodies were assessed and questionnaires filled in at enrolment and days 90–120, 121–180, 181–270, 271–365, and 365–533. Results: Of the 1326 participants, 1191 were CoV(+): 46 ICU, 123 non-ICU, and 1022 outpatients; 135 were CoV(−) outpatient controls. Both CoV(+) outpatients and CoV(−) controls showed high overall symptom rates at all time points. More prevalent among CoV(+) than CoV(−) outpatients were only impaired olfaction and taste; many others proved more frequent for CoV(−) participants. At ≥181 days, fatigue, dyspnoea, various neuropsychological symptoms and several others were recorded more often for CoV(+) inpatients than outpatients. Conclusions: Long COVID-associated symptoms were more frequent among hospitalized than non-hospitalized CoV(+) participants. As for outpatients, only impaired olfaction and taste showed higher rates in the CoV(+) group; some symptoms proved even more common among those CoV(−). Besides suggesting low long COVID prevalences for outpatients, our results highlight the weight of negative controls. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2052-2975 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2052297523001282; https://doaj.org/toc/2052-2975 |
| DOI: |
10.1016/j.nmni.2023.101209 |
| Access URL: |
https://doaj.org/article/a9c3666dc7214441b925d894256240fd |
| Accession Number: |
edsdoj.9c3666dc7214441b925d894256240fd |
| Database: |
Directory of Open Access Journals |
