Academic Journal
Polyclonal alpaca antibodies protect against hantavirus pulmonary syndrome in a lethal Syrian hamster model
| Title: | Polyclonal alpaca antibodies protect against hantavirus pulmonary syndrome in a lethal Syrian hamster model |
|---|---|
| Authors: | Patrycja Sroga, Angela Sloan, Bryce M. Warner, Kevin Tierney, Jocelyne Lew, Guodong Liu, Michael Chan, Yvon Deschambault, Derek R. Stein, Geoff Soule, Logan Banadyga, Darryl Falzarano, David Safronetz |
| Source: | Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
| Publisher Information: | Nature Portfolio, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Medicine, Science |
| More Details: | Abstract The use of antibody-based therapies for the treatment of high consequence viral pathogens has gained interest over the last fifteen years. Here, we sought to evaluate the use of unique camelid-based IgG antibodies to prevent lethal hantavirus pulmonary syndrome (HPS) in Syrian hamsters. Using purified, polyclonal IgG antibodies generated in DNA-immunized alpacas, we demonstrate that post-exposure treatments reduced viral burdens and organ-specific pathology associated with lethal HPS. Antibody treated animals did not exhibit signs of disease and were completely protected. The unique structures and properties, particularly the reduced size, distinct paratope formation and increased solubility of camelid antibodies, in combination with this study support further pre-clinical evaluation of heavy-chain only antibodies for treatment of severe respiratory diseases, including HPS. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 28285301 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-021-96884-6 |
| Access URL: | https://doaj.org/article/9c32e3c2b2f64cb28285301295ae86fb |
| Accession Number: | edsdoj.9c32e3c2b2f64cb28285301295ae86fb |
| Database: | Directory of Open Access Journals |
| Full text is not displayed to guests. | Login for full access. |
| ISSN: | 20452322 28285301 |
|---|---|
| DOI: | 10.1038/s41598-021-96884-6 |
| Published in: | Scientific Reports |
| Language: | English |