Bibliographic Details
| Title: |
Characterization of a cuproptosis-related signature to evaluate immune features and predict prognosis in colorectal cancer |
| Authors: |
Lei Li, Fengyuan Sun, Fanyang Kong, Yongpu Feng, Yingxiao Song, Yiqi Du, Feng Liu, Xiangyu Kong |
| Source: |
Frontiers in Oncology, Vol 13 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
cuproptosis, prognosis, immune infiltration, elesclomol, colorectal cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
PurposeCuproptosis is a newly discovered type of cell death. Little is known about the roles that cuproptosis related genes (CRGs) play in colorectal cancer (CRC). The aim of this study is to evaluate the prognostic value of CRGs and their relationship with tumor immune microenvironment.MethodsTCGA-COAD dataset was used as the training cohort. Pearson correlation was employed to identify CRGs and paired tumor-normal samples were used to identify those CRGs with differential expression pattern. A risk score signature was constructed using LASSO regression and multivariate Cox stepwise regression methods. Two GEO datasets were used as validation cohorts for confirming predictive power and clinical significance of this model. Expression patterns of seven CRGs were evaluated in COAD tissues. In vitro experiments were conducted to validate the expression of the CRGs during cuproptosis.ResultsA total of 771 differentially expressed CRGs were identified in the training cohort. A predictive model termed riskScore was constructed consisting of 7 CRGs and two clinical parameters (age and stage). Survival analysis suggested that patients with higher riskScore showed shorter OS than those with lower (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2234-943X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fonc.2023.1083956/full; https://doaj.org/toc/2234-943X |
| DOI: |
10.3389/fonc.2023.1083956 |
| Access URL: |
https://doaj.org/article/9c0de03c73714c3d8ab3bcc7fc7e4045 |
| Accession Number: |
edsdoj.9c0de03c73714c3d8ab3bcc7fc7e4045 |
| Database: |
Directory of Open Access Journals |
