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Paspalines C–D and Paxillines B–D: New Indole Diterpenoids from Penicillium brefeldianum WZW-F-69

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Title: Paspalines C–D and Paxillines B–D: New Indole Diterpenoids from Penicillium brefeldianum WZW-F-69
Authors: Weiwen Lin, Hanpeng Li, Zhiwen Wu, Jingyi Su, Zehong Zhang, Li Yang, Xianming Deng, Qingyan Xu
Source: Marine Drugs, Vol 20, Iss 11, p 684 (2022)
Publisher Information: MDPI AG, 2022.
Publication Year: 2022
Collection: LCC:Biology (General)
Subject Terms: marine fungus, Penicillium brefeldianum, indole diterpenoids, paspalines, paxillines, cytotoxicity, Biology (General), QH301-705.5
More Details: Five new indole diterpenoids named paspaline C–D (1–2) and paxilline B–D (3–5), as well as eleven known analogues (6–16), were identified from fungus Penicillium brefeldianum strain WZW-F-69, which was isolated from an abalone aquaculture base in Fujian province, China. Their structures were elucidated mainly through 1D- and 2D-NMR spectra analysis and ECD comparison. Compound 1 has a 6/5/5/6/6/8 hexacyclic ring system bearing 2,2-dimethyl-1,3-dioxocane, which is rare in natural products. Compound 2 has an unusual open F-ring structure. The cytotoxic activities against 10 cancer cell lines and antimicrobial activities against model bacteria and fungi of all compounds were assayed. No compound showed antimicrobial activity, but at a concentration of 1 μM, compounds 1 and 6 exhibited the highest inhibition rates of 71.2% and 83.4% against JeKo-1 cells and U2OS cells, respectively.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1660-3397
Relation: https://www.mdpi.com/1660-3397/20/11/684; https://doaj.org/toc/1660-3397
DOI: 10.3390/md20110684
Access URL: https://doaj.org/article/9bfcabd5dfad46cbbef14077d4050b8f
Accession Number: edsdoj.9bfcabd5dfad46cbbef14077d4050b8f
Database: Directory of Open Access Journals
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  Data: Paspalines C–D and Paxillines B–D: New Indole Diterpenoids from Penicillium brefeldianum WZW-F-69
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  Data: <searchLink fieldCode="AR" term="%22Weiwen+Lin%22">Weiwen Lin</searchLink><br /><searchLink fieldCode="AR" term="%22Hanpeng+Li%22">Hanpeng Li</searchLink><br /><searchLink fieldCode="AR" term="%22Zhiwen+Wu%22">Zhiwen Wu</searchLink><br /><searchLink fieldCode="AR" term="%22Jingyi+Su%22">Jingyi Su</searchLink><br /><searchLink fieldCode="AR" term="%22Zehong+Zhang%22">Zehong Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Li+Yang%22">Li Yang</searchLink><br /><searchLink fieldCode="AR" term="%22Xianming+Deng%22">Xianming Deng</searchLink><br /><searchLink fieldCode="AR" term="%22Qingyan+Xu%22">Qingyan Xu</searchLink>
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  Data: Marine Drugs, Vol 20, Iss 11, p 684 (2022)
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  Data: MDPI AG, 2022.
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  Data: 2022
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  Data: <searchLink fieldCode="DE" term="%22marine+fungus%22">marine fungus</searchLink><br /><searchLink fieldCode="DE" term="%22Penicillium+brefeldianum%22">Penicillium brefeldianum</searchLink><br /><searchLink fieldCode="DE" term="%22indole+diterpenoids%22">indole diterpenoids</searchLink><br /><searchLink fieldCode="DE" term="%22paspalines%22">paspalines</searchLink><br /><searchLink fieldCode="DE" term="%22paxillines%22">paxillines</searchLink><br /><searchLink fieldCode="DE" term="%22cytotoxicity%22">cytotoxicity</searchLink><br /><searchLink fieldCode="DE" term="%22Biology+%28General%29%22">Biology (General)</searchLink><br /><searchLink fieldCode="DE" term="%22QH301-705%2E5%22">QH301-705.5</searchLink>
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  Data: Five new indole diterpenoids named paspaline C–D (1–2) and paxilline B–D (3–5), as well as eleven known analogues (6–16), were identified from fungus Penicillium brefeldianum strain WZW-F-69, which was isolated from an abalone aquaculture base in Fujian province, China. Their structures were elucidated mainly through 1D- and 2D-NMR spectra analysis and ECD comparison. Compound 1 has a 6/5/5/6/6/8 hexacyclic ring system bearing 2,2-dimethyl-1,3-dioxocane, which is rare in natural products. Compound 2 has an unusual open F-ring structure. The cytotoxic activities against 10 cancer cell lines and antimicrobial activities against model bacteria and fungi of all compounds were assayed. No compound showed antimicrobial activity, but at a concentration of 1 μM, compounds 1 and 6 exhibited the highest inhibition rates of 71.2% and 83.4% against JeKo-1 cells and U2OS cells, respectively.
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  Data: https://www.mdpi.com/1660-3397/20/11/684; https://doaj.org/toc/1660-3397
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        StartPage: 684
    Subjects:
      – SubjectFull: marine fungus
        Type: general
      – SubjectFull: Penicillium brefeldianum
        Type: general
      – SubjectFull: indole diterpenoids
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      – SubjectFull: paspalines
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      – SubjectFull: paxillines
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      – TitleFull: Paspalines C–D and Paxillines B–D: New Indole Diterpenoids from Penicillium brefeldianum WZW-F-69
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            NameFull: Weiwen Lin
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