Bibliographic Details
| Title: |
Paspalines C–D and Paxillines B–D: New Indole Diterpenoids from Penicillium brefeldianum WZW-F-69 |
| Authors: |
Weiwen Lin, Hanpeng Li, Zhiwen Wu, Jingyi Su, Zehong Zhang, Li Yang, Xianming Deng, Qingyan Xu |
| Source: |
Marine Drugs, Vol 20, Iss 11, p 684 (2022) |
| Publisher Information: |
MDPI AG, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
marine fungus, Penicillium brefeldianum, indole diterpenoids, paspalines, paxillines, cytotoxicity, Biology (General), QH301-705.5 |
| More Details: |
Five new indole diterpenoids named paspaline C–D (1–2) and paxilline B–D (3–5), as well as eleven known analogues (6–16), were identified from fungus Penicillium brefeldianum strain WZW-F-69, which was isolated from an abalone aquaculture base in Fujian province, China. Their structures were elucidated mainly through 1D- and 2D-NMR spectra analysis and ECD comparison. Compound 1 has a 6/5/5/6/6/8 hexacyclic ring system bearing 2,2-dimethyl-1,3-dioxocane, which is rare in natural products. Compound 2 has an unusual open F-ring structure. The cytotoxic activities against 10 cancer cell lines and antimicrobial activities against model bacteria and fungi of all compounds were assayed. No compound showed antimicrobial activity, but at a concentration of 1 μM, compounds 1 and 6 exhibited the highest inhibition rates of 71.2% and 83.4% against JeKo-1 cells and U2OS cells, respectively. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1660-3397 |
| Relation: |
https://www.mdpi.com/1660-3397/20/11/684; https://doaj.org/toc/1660-3397 |
| DOI: |
10.3390/md20110684 |
| Access URL: |
https://doaj.org/article/9bfcabd5dfad46cbbef14077d4050b8f |
| Accession Number: |
edsdoj.9bfcabd5dfad46cbbef14077d4050b8f |
| Database: |
Directory of Open Access Journals |
