Bibliographic Details
| Title: |
Severe Asthma in School-Age Children: An Updated Appraisal on Biological Options and Challenges in This Age Group |
| Authors: |
Cristiana Indolfi, Angela Klain, Maria Cristina Capuano, Simone Colosimo, Renata Rapillo, Michele Miraglia del Giudice |
| Source: |
Children, Vol 12, Iss 2, p 167 (2025) |
| Publisher Information: |
MDPI AG, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Pediatrics |
| Subject Terms: |
severe asthma, children, school-age, treatment, biologicals, biomarkers, Pediatrics, RJ1-570 |
| More Details: |
This review examines the growing role of biological therapies in managing severe asthma in children aged 6–11 years. Severe asthma, characterized by persistent symptoms and frequent exacerbations, presents significant challenges in pediatric care. Biologic treatments, including mepolizumab, omalizumab, and dupilumab, provide targeted interventions for patients with high eosinophilic inflammation or allergic asthma (T2-high asthma). Alongside their therapeutic benefits, the review evaluates the safety profiles of these biologics, highlighting potential side effects and the necessity for monitoring during long-term use. Cost considerations and treatment adherence also emerge as important challenges that need to be addressed in clinical practice. Additionally, the review emphasizes the need for identifying patients who would derive the most benefit from biologic therapies, advocating for the development of biomarkers to aid in treatment decisions. Emerging biologics, such as tezepelumab, are introduced as promising alternatives with the potential to target upstream inflammatory pathways, offering hope for treating T2-low asthma forms, which currently lack effective treatment options in children. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2227-9067 |
| Relation: |
https://www.mdpi.com/2227-9067/12/2/167; https://doaj.org/toc/2227-9067 |
| DOI: |
10.3390/children12020167 |
| Access URL: |
https://doaj.org/article/9bee614a30b240f6b7dadc3e7eb7c70e |
| Accession Number: |
edsdoj.9bee614a30b240f6b7dadc3e7eb7c70e |
| Database: |
Directory of Open Access Journals |
