Academic Journal
Caudate nucleus volume in medicated and unmedicated patients with early- and adult-onset schizophrenia
| Title: | Caudate nucleus volume in medicated and unmedicated patients with early- and adult-onset schizophrenia |
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| Authors: | Dimitrios Andreou, Kjetil Nordbø Jørgensen, Stener Nerland, Tereza Calkova, Lynn Mørch-Johnsen, Runar Elle Smelror, Laura A. Wortinger, Mathias Lundberg, Hannes Bohman, Anne Margrethe Myhre, Erik G. Jönsson, Ole A. Andreassen, Ingrid Agartz |
| Source: | Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024) |
| Publisher Information: | Nature Portfolio, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Caudate, MRI, Schizophrenia, Early-onset, Adult-onset, Antipsychotics, Medicine, Science |
| More Details: | Abstract The caudate nucleus is a part of the striatum, and striatal hyperdopaminergia is considered central to the pathophysiology of schizophrenia. How caudate volume is affected in schizophrenia and what role antipsychotics play remains unclear. In early-onset schizophrenia (EOS), where psychosis emerges during a neurodevelopmentally critical phase, the caudate may exhibit a heightened vulnerability to the effects of antipsychotic medications. We hypothesized effects of both antipsychotic medication use and age of onset on caudate in schizophrenia. We included adult patients with EOS (n = 83) and adult-onset schizophrenia (AOS) (n = 246), adult healthy controls (HC, n = 774), adolescent patients with non-affective psychosis (n = 56) and adolescent HC (n = 97). We obtained T1-weighted MRI scans using a 1.5T Siemens scanner and General Electric 3T scanners. In our main analysis, we tested for main and interaction effects of diagnosis and current antipsychotic medication use on caudate volume. Adult patients with EOS (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-73322-x |
| Access URL: | https://doaj.org/article/9b21ef4184e4494c89d781b988c9882c |
| Accession Number: | edsdoj.9b21ef4184e4494c89d781b988c9882c |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-024-73322-x |
| Published in: | Scientific Reports |
| Language: | English |