Rescue Therapy with a Proton Pump Inhibitor Plus Amoxicillin and Rifabutin for Helicobacter pylori Infection: A Systematic Review and Meta-Analysis
| Title: | Rescue Therapy with a Proton Pump Inhibitor Plus Amoxicillin and Rifabutin for Helicobacter pylori Infection: A Systematic Review and Meta-Analysis |
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| Authors: | Xiaoqun Liu, Hui Wang, Zhifa Lv, Youhua Wang, Ben Wang, Yong Xie, Xiaojiang Zhou, Nonghua Lv |
| Source: | Gastroenterology Research and Practice, Vol 2015 (2015) |
| Publisher Information: | Wiley, 2015. |
| Publication Year: | 2015 |
| Collection: | LCC:Diseases of the digestive system. Gastroenterology |
| Subject Terms: | Diseases of the digestive system. Gastroenterology, RC799-869 |
| More Details: | Background. To conduct a systematic review and meta-analysis of clinical trials for eradication of Helicobacter pylori (H. pylori) that included a treatment arm with a proton pump inhibitor, rifabutin, and amoxicillin. Materials and Methods. We selected clinical trials that examined the efficacy of H. pylori eradication therapies and included a study arm using the test regimen from major medical literature databases and abstracts from major gastroenterology meetings. We also did subgroup and sensitivity analyses. Results. Twenty-one studies were included in systematic review. The total eradication rates of the test regimen were 70.4% by intent-to-treat (ITT) and 72.0% by per-protocol (PP) analyses. The pooled odds ratio (OR) was 0.55 using fixed effects model (P=0.283) for the test regimen versus other triple regimens. The total eradication rates were 68.4% for the test regimen and 81.9% in the control group by ITT, while the OR was 1.08 using random effects model (P=0.019). The pooled eradication rate was 66.4% for the test regimen and 67.4% for the control group by ITT. The total adverse effects incidence were 25.1% for the test regimen. Conclusions. The test regimen for H. pylori rescue therapy may be not superior to control regimens in efficacy. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1687-6121 1687-630X |
| Relation: | https://doaj.org/toc/1687-6121; https://doaj.org/toc/1687-630X |
| DOI: | 10.1155/2015/415648 |
| Access URL: | https://doaj.org/article/9ac4092a2ce34fcbaf603760d2942286 |
| Accession Number: | edsdoj.9ac4092a2ce34fcbaf603760d2942286 |
| Database: | Directory of Open Access Journals |
| ISSN: | 16876121 1687630X |
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| DOI: | 10.1155/2015/415648 |
| Published in: | Gastroenterology Research and Practice |
| Language: | English |