Tetrahydrocurcumin Ameliorates Kidney Injury and High Systolic Blood Pressure in High-Fat Diet-Induced Type 2 Diabetic Mice
| Title: | Tetrahydrocurcumin Ameliorates Kidney Injury and High Systolic Blood Pressure in High-Fat Diet-Induced Type 2 Diabetic Mice |
|---|---|
| Authors: | Weerapon Sangartit, Kyung Bong Ha, Eun Soo Lee, Hong Min Kim, Upa Kukongviriyapan, Eun Young Lee, Choon Hee Chung |
| Source: | Endocrinology and Metabolism, Vol 36, Iss 4, Pp 810-822 (2021) |
| Publisher Information: | Korean Endocrine Society, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: | diabetic nephropathies, renin-angiotensin system, hypertension, tetrahydrocurcumin, curcumin, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: | Background Activation of the intrarenal renin-angiotensin system (RAS) is implicated in the pathogenesis of kidney injury and hypertension. We aimed to investigate the protective effect of tetrahydrocurcumin (THU) on intrarenal RAS expression, kidney injury, and systolic blood pressure (SBP) in high-fat diet (HFD)-induced type 2 diabetic mice. Methods Eight-week-old male mice were fed a regular diet (RD) or HFD for 12 weeks, and THU (50 or 100 mg/kg/day) was intragastrically administered with HFD. Physiological and metabolic changes were monitored and the expression of RAS components and markers of kidney injury were assessed. Results HFD-fed mice exhibited hyperglycemia, insulin resistance, and dyslipidemia compared to those in the RD group (P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English Korean |
| ISSN: | 2093-596X 2093-5978 |
| Relation: | http://www.e-enm.org/upload/pdf/enm-2021-988.pdf; https://doaj.org/toc/2093-596X; https://doaj.org/toc/2093-5978 |
| DOI: | 10.3803/EnM.2021.988 |
| Access URL: | https://doaj.org/article/9aacaa93b2884ae88e267384eb395795 |
| Accession Number: | edsdoj.9aacaa93b2884ae88e267384eb395795 |
| Database: | Directory of Open Access Journals |
| ISSN: | 2093596X 20935978 |
|---|---|
| DOI: | 10.3803/EnM.2021.988 |
| Published in: | Endocrinology and Metabolism |
| Language: | English Korean |