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Unveiling the association between long non-coding RNAs (RP5-833A20.1, DYNLRB2-2, and APOA1-AS) and ischemic stroke: exploring biomarkers, and clinical implications

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Title: Unveiling the association between long non-coding RNAs (RP5-833A20.1, DYNLRB2-2, and APOA1-AS) and ischemic stroke: exploring biomarkers, and clinical implications
Authors: Mahnaz Bayat, Mahsa Mokhtari, Mohammad Javad Mokhtari, Negin Gharbi, Reza Tabrizi, Mohammad Saied Salehi, Najmeh Karimi, Moosa Rahimi, Etrat Hooshmandi, Seyedeh Shaghayegh Zafarmand, Maryam Owjfard, Ramin Lashanizadegan, Mahintaj Dara, Afshin Borhani-Haghighi
Source: Egyptian Journal of Medical Human Genetics, Vol 26, Iss 1, Pp 1-11 (2025)
Publisher Information: SpringerOpen, 2025.
Publication Year: 2025
Collection: LCC:Medicine (General)
LCC:Genetics
Subject Terms: Long non-coding RNAs, RP5-833A20.1, DYNLRB2-2, APOA1 antisense, Ischemic stroke, Medicine (General), R5-920, Genetics, QH426-470
More Details: Abstract Background RP5-833A20.1, DYNLRB2-2, and APOA1 antisense are pivotal in atherosclerotic plaque pathogenesis. This study examined whether changes in these circulating lncRNAs could serve as biomarkers for high-risk ischemic stroke (IS) patients with intracranial atherosclerotic disease (ICAD). Methods Sixty-three IS patients, presenting within the first 24 h after stroke onset, and 60 controls were included in the study. The circulating levels of RP5-833A20.1, DYNLRB2-2, and APOA1 antisense in IS patients were assessed using real-time polymerase chain reaction (RT-PCR). Results Significant decreases in the circulating levels of DYNLRB2-2 and RP5-833A20.1 were observed in IS patients compared to controls (P
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2090-2441
Relation: https://doaj.org/toc/2090-2441
DOI: 10.1186/s43042-025-00658-y
Access URL: https://doaj.org/article/9a98a1d25cde40c89f4ac0b2167038c3
Accession Number: edsdoj.9a98a1d25cde40c89f4ac0b2167038c3
Database: Directory of Open Access Journals
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More Details
ISSN:20902441
DOI:10.1186/s43042-025-00658-y
Published in:Egyptian Journal of Medical Human Genetics
Language:English