Academic Journal
Differentiation of IL-26+ TH17 intermediates into IL-17A producers via epithelial crosstalk in psoriasis
| Title: | Differentiation of IL-26+ TH17 intermediates into IL-17A producers via epithelial crosstalk in psoriasis |
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| Authors: | Anissa Fries, Fanny Saidoune, François Kuonen, Isabelle Dupanloup, Nadine Fournier, Ana Cristina Guerra de Souza, Muzlifah Haniffa, Feiyang Ma, Johann E. Gudjonsson, Lennart Roesner, Yang Li, Thomas Werfel, Curdin Conrad, Raphael Gottardo, Robert L. Modlin, Jeremy Di Domizio, Michel Gilliet |
| Source: | Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023) |
| Publisher Information: | Nature Portfolio, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Science |
| Subject Terms: | Science |
| More Details: | Abstract Interleukin (IL)-26 is a TH17 cytokine with known antimicrobial and pro-inflammatory functions. However, the precise role of IL-26 in the context of pathogenic TH17 responses is unknown. Here we identify a population of blood TH17 intermediates that produce high levels of IL-26 and differentiate into IL-17A-producing TH17 cells upon TGF-β1 exposure. By combining single cell RNA sequencing, TCR sequencing and spatial transcriptomics we show that this process occurs in psoriatic skin. In fact, IL-26+ TH17 intermediates infiltrating psoriatic skin induce TGF-β1 expression in basal keratinocytes and thereby promote their own differentiation into IL-17A-producing cells. Thus, our study identifies IL-26-producing cells as an early differentiation stage of TH17 cells that infiltrates psoriatic skin and controls its own maturation into IL17A-producing TH17 cells, via epithelial crosstalk involving paracrine production of TGF-β1. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2041-1723 49605240 |
| Relation: | https://doaj.org/toc/2041-1723 |
| DOI: | 10.1038/s41467-023-39484-4 |
| Access URL: | https://doaj.org/article/9a6badc4e12148d591a4960524014626 |
| Accession Number: | edsdoj.9a6badc4e12148d591a4960524014626 |
| Database: | Directory of Open Access Journals |
| ISSN: | 20411723 49605240 |
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| DOI: | 10.1038/s41467-023-39484-4 |
| Published in: | Nature Communications |
| Language: | English |