Bibliographic Details
| Title: |
Metabolism of beta-muricholic acid in the hamster and prairie dog |
| Authors: |
S Miki, EH Mosbach, BI Cohen, T Mikami, R Infante, N Ayyad, CK McSherry |
| Source: |
Journal of Lipid Research, Vol 34, Iss 10, Pp 1709-1716 (1993) |
| Publisher Information: |
Elsevier, 1993. |
| Publication Year: |
1993 |
| Collection: |
LCC:Biochemistry |
| Subject Terms: |
Biochemistry, QD415-436 |
| More Details: |
The metabolism of beta-muricholic acid was investigated in the prairie dog and the hamster. Intravenous infusion into bile fistula hamsters showed that beta-muricholic acid was extracted by the liver and secreted into the bile (> 85% in 1 h). Hepatic extraction of this compound and cholic acid in the prairie dog was not as rapid as in the hamster. In the bile of the prairie dog, most (93%) of the administered beta-muricholic acid was present as the taurine conjugate. In the hamster, 28% of infused beta-muricholic acid was secreted in unconjugated form, 43% as the taurine conjugate, and 22% as the glycine conjugate. In both species, the administered compound underwent little biotransformation. After intraduodenal injection of [6 alpha-3H]-labeled beta-muricholic acid into bile fistula hamsters, the bile acid was rapidly secreted into the bile; more than 80% of the administered radioactivity was recovered in 3 h. In the prairie dog, biliary recovery after intraduodenal administration of either beta-muricholic acid (43% in 3 h) or cholic acid (22% in 3 h) was slower than in the hamster. After intragastric administration, more than 80% of beta-muricholic acid was recovered unchanged in feces of both animal species. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
0022-2275 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S0022227520357333; https://doaj.org/toc/0022-2275 |
| DOI: |
10.1016/S0022-2275(20)35733-3 |
| Access URL: |
https://doaj.org/article/9a192dc1b52f47ed97a51b3acbda960e |
| Accession Number: |
edsdoj.9a192dc1b52f47ed97a51b3acbda960e |
| Database: |
Directory of Open Access Journals |
