Bibliographic Details
| Title: |
Transcriptional profile of Mycobacterium tuberculosis infection in people living with HIV |
| Authors: |
Burcu Tepekule, Lisa Jörimann, Corinne D. Schenkel, Lennart Opitz, Jasmin Tschumi, Rebekka Wolfensberger, Kathrin Neumann, Katharina Kusejko, Marius Zeeb, Lucas Boeck, Marisa Kälin, Julia Notter, Hansjakob Furrer, Matthias Hoffmann, Hans H. Hirsch, Alexandra Calmy, Matthias Cavassini, Niklaus D. Labhardt, Enos Bernasconi, Gabriela Oesch, Karin J. Metzner, Dominique L. Braun, Huldrych F. Günthard, Roger D. Kouyos, Fergal Duffy, Johannes Nemeth |
| Source: |
iScience, Vol 27, Iss 11, Pp 111228- (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Science |
| Subject Terms: |
Health sciences, Microbiology, Transcriptomics, Science |
| More Details: |
Summary: In people with HIV-1 (PWH), Mycobacterium tuberculosis (MTB) infection poses a significant threat. While active tuberculosis (TB) accelerates immunodeficiency, the interaction between MTB and HIV-1 during asymptomatic phases remains unclear. Analysis of peripheral blood mononuclear cells (PBMC) transcriptomic profiles in PWH, with and without controlled viral loads, revealed distinct clustering in MTB-infected individuals. Functional annotation identified alterations in IL-6, TNF, and KRAS pathways. Notably, MTB-related genes displayed an inverse correlation with HIV-1 viremia, at both individual and signature score levels. These findings suggest that MTB infection in PWH induces a shift in immune system activation, inversely related to HIV-1 viral load. These results may explain the observed enhanced antiretroviral control in MTB-infected PWH. This study highlights the complex interplay between MTB and HIV-1, emphasizing the importance of understanding their interaction for managing co-infections in this population. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2589-0042 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2589004224024532; https://doaj.org/toc/2589-0042 |
| DOI: |
10.1016/j.isci.2024.111228 |
| Access URL: |
https://doaj.org/article/9a0f0af5bac64596afefb67ddc130c6e |
| Accession Number: |
edsdoj.9a0f0af5bac64596afefb67ddc130c6e |
| Database: |
Directory of Open Access Journals |
