Academic Journal
Functional MRI correlates of emotion regulation in major depressive disorder related to depressive disease load measured over nine years
| Title: | Functional MRI correlates of emotion regulation in major depressive disorder related to depressive disease load measured over nine years |
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| Authors: | Rozemarijn S. van Kleef, Amke Müller, Laura S. van Velzen, Janna Marie Bas-Hoogendam, Nic J.A. van der Wee, Lianne Schmaal, Dick J. Veltman, Maria M. Rive, Henricus G. Ruhé, Jan-Bernard C. Marsman, Marie-José van Tol |
| Source: | NeuroImage: Clinical, Vol 40, Iss , Pp 103535- (2023) |
| Publisher Information: | Elsevier, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Computer applications to medicine. Medical informatics LCC:Neurology. Diseases of the nervous system |
| Subject Terms: | Depression, Emotion regulation, Disease load, Functional connectivity, Brain activity, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: | Major Depressive Disorder (MDD) often is a recurrent and chronic disorder. We investigated the neurocognitive underpinnings of the incremental risk for poor disease course by exploring relations between enduring depression and brain functioning during regulation of negative and positive emotions using cognitive reappraisal.We used fMRI-data from the longitudinal Netherlands Study of Depression and Anxiety acquired during an emotion regulation task in 77 individuals with MDD. Task-related brain activity was related to disease load, calculated from presence and severity of depression in the preceding nine years. Additionally, we explored task related brain-connectivity. Brain functioning in individuals with MDD was further compared to 35 controls to explore overlap between load-effects and general effects related to MDD history/presence.Disease load was not associated with changes in affect or with brain activity, but with connectivity between areas essential for processing, integrating and regulating emotional information during downregulation of negative emotions. Results did not overlap with general MDD-effects. Instead, MDD was generally associated with lower parietal activity during downregulation of negative emotions. During upregulation of positive emotions, disease load was related to connectivity between limbic regions (although driven by symptomatic state), and connectivity between frontal, insular and thalamic regions was lower in MDD (vs controls).Results suggest that previous depressive load relates to brain connectivity in relevant networks during downregulation of negative emotions. These abnormalities do not overlap with disease-general abnormalities and could foster an incremental vulnerability to recurrence or chronicity of MDD. Therefore, optimizing emotion regulation is a promising therapeutic target for improving long-term MDD course. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2213-1582 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2213158223002267; https://doaj.org/toc/2213-1582 |
| DOI: | 10.1016/j.nicl.2023.103535 |
| Access URL: | https://doaj.org/article/d99ff33af71143b1ac6afd71b9eeef7f |
| Accession Number: | edsdoj.99ff33af71143b1ac6afd71b9eeef7f |
| Database: | Directory of Open Access Journals |
| ISSN: | 22131582 |
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| DOI: | 10.1016/j.nicl.2023.103535 |
| Published in: | NeuroImage: Clinical |
| Language: | English |