Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation.
| Title: | Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation. |
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| Authors: | Mohamed Abdel-Mohsen, Leonard Chavez, Ravi Tandon, Glen M Chew, Xutao Deng, Ali Danesh, Sheila Keating, Marion Lanteri, Michael L Samuels, Rebecca Hoh, Jonah B Sacha, Philip J Norris, Toshiro Niki, Cecilia M Shikuma, Mitsuomi Hirashima, Steven G Deeks, Lishomwa C Ndhlovu, Satish K Pillai |
| Source: | PLoS Pathogens, Vol 12, Iss 6, p e1005677 (2016) |
| Publisher Information: | Public Library of Science (PLoS), 2016. |
| Publication Year: | 2016 |
| Collection: | LCC:Immunologic diseases. Allergy LCC:Biology (General) |
| Subject Terms: | Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5 |
| More Details: | Identifying host immune determinants governing HIV transcription, latency and infectivity in vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 regulates HIV transcription during antiretroviral therapy (ART), and published data demonstrating that the human carbohydrate-binding immunomodulatory protein galectin-9 regulates p21, we hypothesized that galectin-9 modulates HIV transcription. We report that the administration of a recombinant, stable form of galectin-9 (rGal-9) potently reverses HIV latency in vitro in the J-Lat HIV latency model. Furthermore, rGal-9 reverses HIV latency ex vivo in primary CD4+ T cells from HIV-infected, ART-suppressed individuals (p = 0.002), more potently than vorinostat (p = 0.02). rGal-9 co-administration with the latency reversal agent "JQ1", a bromodomain inhibitor, exhibits synergistic activity (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1553-7366 1553-7374 |
| Relation: | https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374 |
| DOI: | 10.1371/journal.ppat.1005677 |
| Access URL: | https://doaj.org/article/99df66f3b2f4407eb323bcc5b84708fd |
| Accession Number: | edsdoj.99df66f3b2f4407eb323bcc5b84708fd |
| Database: | Directory of Open Access Journals |
| ISSN: | 15537366 15537374 |
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| DOI: | 10.1371/journal.ppat.1005677 |
| Published in: | PLoS Pathogens |
| Language: | English |