Academic Journal
Nationwide retrospective study of critically ill adults with sickle cell disease in France
| Title: | Nationwide retrospective study of critically ill adults with sickle cell disease in France |
|---|---|
| Authors: | Maïté Agbakou, Armand Mekontso-Dessap, Morgane Pere, Guillaume Voiriot, Muriel Picard, Jérémy Bourenne, Stephan Ehrmann, Emmanuel Canet, Alexandre Boyer, Saad Nseir, Fabienne Tamion, Arnaud W. Thille, Laurent Argaud, Emmanuel Pontis, Jean-Pierre Quenot, Francis Schneider, Arnaud Hot, Gilles Capellier, Cécile Aubron, Keyvan Razazi, Agathe Masseau, Noëlle Brule, Jean Reignier, Jean-Baptiste Lascarrou |
| Source: | Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| Publisher Information: | Nature Portfolio, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Medicine, Science |
| More Details: | Abstract Little is known about patients with sickle cell disease (SCD) who require intensive care unit (ICU) admission. The goals of this study were to assess outcomes in patients admitted to the ICU for acute complications of SCD and to identify factors associated with adverse outcomes. This multicenter retrospective study included consecutive adults with SCD admitted to one of 17 participating ICUs. An adverse outcome was defined as death or a need for life-sustaining therapies (non-invasive or invasive ventilation, vasoactive drugs, renal replacement therapy, and/or extracorporeal membrane oxygenation). Factors associated with adverse outcomes were identified by mixed multivariable logistic regression. We included 488 patients admitted in 2015–2017. The main reasons for ICU admission were acute chest syndrome (47.5%) and severely painful vaso-occlusive event (21.3%). Sixteen (3.3%) patients died in the ICU, mainly of multi-organ failure following a painful vaso-occlusive event or sepsis. An adverse outcome occurred in 81 (16.6%; 95% confidence interval [95% CI], 13.3%–19.9%) patients. Independent factors associated with adverse outcomes were low mean arterial blood pressure (adjusted odds ratio [aOR], 0.98; 95% CI 0.95–0.99; p = 0.027), faster respiratory rate (aOR, 1.09; 95% CI 1.05–1.14; p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-021-02437-2 |
| Access URL: | https://doaj.org/article/998cf3b3f4ca4aed85d72460396144b3 |
| Accession Number: | edsdoj.998cf3b3f4ca4aed85d72460396144b3 |
| Database: | Directory of Open Access Journals |
| Full text is not displayed to guests. | Login for full access. |
| ISSN: | 20452322 |
|---|---|
| DOI: | 10.1038/s41598-021-02437-2 |
| Published in: | Scientific Reports |
| Language: | English |