Academic Journal
Nanoparticles for the treatment of spinal cord injury
| Title: | Nanoparticles for the treatment of spinal cord injury |
|---|---|
| Authors: | Qiwei Yang, Di Lu, Jiuping Wu, Fuming Liang, Huayi Wang, Junjie Yang, Ganggang Zhang, Chen Wang, Yanlian Yang, Ling Zhu, Xinzhi Sun |
| Source: | Neural Regeneration Research, Vol 20, Iss 6, Pp 1665-1680 (2025) |
| Publisher Information: | Wolters Kluwer Medknow Publications, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Neurology. Diseases of the nervous system |
| Subject Terms: | antioxidants, axon regeneration, biocompatible materials, drug carriers, nanoparticles, nerve regeneration, neuroinflammatory diseases, neuroprotection, spinal cord injury, stem cells, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: | Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1673-5374 1876-7958 |
| Relation: | https://journals.lww.com/10.4103/NRR.NRR-D-23-01848; https://doaj.org/toc/1673-5374; https://doaj.org/toc/1876-7958 |
| DOI: | 10.4103/NRR.NRR-D-23-01848 |
| Access URL: | https://doaj.org/article/98a5b328e47548e3b347d43c6db150f4 |
| Accession Number: | edsdoj.98a5b328e47548e3b347d43c6db150f4 |
| Database: | Directory of Open Access Journals |
| ISSN: | 16735374 18767958 |
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| DOI: | 10.4103/NRR.NRR-D-23-01848 |
| Published in: | Neural Regeneration Research |
| Language: | English |