Bibliographic Details
| Title: |
Overexpression of the insulin receptor isoform A promotes endometrial carcinoma cell growth. |
| Authors: |
Chun-Fang Wang, Guo Zhang, Li-Jun Zhao, Wen-Juan Qi, Xiao-Ping Li, Jian-Liu Wang, Li-Hui Wei |
| Source: |
PLoS ONE, Vol 8, Iss 8, p e69001 (2013) |
| Publisher Information: |
Public Library of Science (PLoS), 2013. |
| Publication Year: |
2013 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
Epidemiological studies have demonstrated that type 2 diabetes mellitus (T2DM) and hyperinsulinemia are associated closely with endometrial carcinoma risk, although the molecular mechanism remains unclear. Insulin receptor isoformA expression is upregulated in many cancer cells and tissues, which suggests that IR-A-mediated signaling pathways may have important implications for cancer pathogenesis. We measured the expression of insulin receptor isoforms (IR-A and IR-B in the normal endometrium tissues, the endometrial carcinoma tissues and the endometrial carcinoma cell lines. We found that the total insulin receptor (IR) and IR-A expression mRNA levels and the ratio of IR-A to total IR in endometrial carcinoma specimens were significantly higher than them in control endometrial tissue specimens(P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
http://europepmc.org/articles/PMC3737217?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: |
10.1371/journal.pone.0069001 |
| Access URL: |
https://doaj.org/article/9887dfa4c3d447f9a1ad00c856c851ba |
| Accession Number: |
edsdoj.9887dfa4c3d447f9a1ad00c856c851ba |
| Database: |
Directory of Open Access Journals |
