Bibliographic Details
| Title: |
Effects of definitive chemoradiation on circulating immunologic angiogenic cytokines in head and neck cancer patients |
| Authors: |
F. Stephen Hodi, Jonathan Schoenfeld, Mariano Severgnini, Vishwajith Sridharan, Danielle N. Margalit, Stephanie A. Lynch, Robert I. Haddad, Roy B. Tishler |
| Source: |
Journal for ImmunoTherapy of Cancer, Vol 4, Iss 1 (2016) |
| Publisher Information: |
BMJ Publishing Group, 2016. |
| Publication Year: |
2016 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Background Preclinical studies suggest a synergistic effect between radiation, immunotherapy and anti-angiogenic therapy, although the mechanisms are unclear. Angiogenic cytokines are known to affect the immune system, and their levels may be associated with response to immunotherapy. Here, we assess changes in circulating VEGF, as well as angiogenic cytokines angiopoietin-1 and -2 (Ang1, Ang2), and placental growth factor (PLGF) that occur during definitive chemo-radiotherapy in HNSCC patients.Methods We prospectively collected blood samples from patients receiving definitive radiation with or without chemotherapy. Serum Ang1, Ang2, VEGF, and PLGF were measured via cytokine assays.Results The majority of patients had advanced stage, node positive HPV-associated oropharyngeal cancer, and received radiation to a median dose of 70 Gy with concurrent cisplatin. Over the course of treatment, serum VEGF and Ang1 levels decreased in 20/24 (84 %, p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2051-1426 |
| Relation: |
https://jitc.bmj.com/content/4/1/32.full; https://doaj.org/toc/2051-1426 |
| DOI: |
10.1186/s40425-016-0138-9 |
| Access URL: |
https://doaj.org/article/9885852f7f7f461d93162f27413a47bc |
| Accession Number: |
edsdoj.9885852f7f7f461d93162f27413a47bc |
| Database: |
Directory of Open Access Journals |
