Academic Journal
The role of colonic microbiota amino acid metabolism in gut health regulation
| Title: | The role of colonic microbiota amino acid metabolism in gut health regulation |
|---|---|
| Authors: | Youli Chen, Jing-Yuan Fang |
| Source: | Cell Insight, Vol 4, Iss 2, Pp 100227- (2025) |
| Publisher Information: | Elsevier, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Biology (General) LCC:Medicine (General) |
| Subject Terms: | Amino acids, Human gut microbiota, Metabolism, Gastrointestinal diseases, Biology (General), QH301-705.5, Medicine (General), R5-920 |
| More Details: | The human gut microbiota plays a critical role in maintaining host homeostasis through metabolic activities. Among these, amino acid (AA) metabolism by the microbiota in the large intestine is highly heterogeneous and relevant to host health. Despite increasing interest, microbial AA metabolism remains relatively unexplored. This review highlights recent advances in colonic microbial AA metabolism, including auxotrophies, AA synthesis, and dissimilatory AA metabolites, and their implications in gut health, focusing on major gastrointestinal diseases including colorectal cancer, inflammatory bowel disease, and irritable bowel syndrome. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2772-8927 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S277289272500001X; https://doaj.org/toc/2772-8927 |
| DOI: | 10.1016/j.cellin.2025.100227 |
| Access URL: | https://doaj.org/article/97f6845cf4374dc08c535febc4faf3c6 |
| Accession Number: | edsdoj.97f6845cf4374dc08c535febc4faf3c6 |
| Database: | Directory of Open Access Journals |
| ISSN: | 27728927 |
|---|---|
| DOI: | 10.1016/j.cellin.2025.100227 |
| Published in: | Cell Insight |
| Language: | English |