Academic Journal
Potential pathological mechanisms and pharmacological interventions for cadmium-induced miscarriage
| Title: | Potential pathological mechanisms and pharmacological interventions for cadmium-induced miscarriage |
|---|---|
| Authors: | Yufei Li, Juan Liu, Na Ran, Changwu Zheng, PingPing Wang, Jiayi Li, Yumeng Fang, Danna Fang, Yeling Ma |
| Source: | Ecotoxicology and Environmental Safety, Vol 273, Iss , Pp 116118- (2024) |
| Publisher Information: | Elsevier, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Environmental pollution LCC:Environmental sciences |
| Subject Terms: | Cadmium, Miscarriage, Mechanism, Pharmacological intervention, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350 |
| More Details: | The prevalence of cadmium (Cd) contamination has emerged as a significant global concern. Exposure to Cd during pregnancy is associated with adverse pregnancy outcomes, including miscarriage. However, there is currently a lack of comprehensive summaries on Cd-induced miscarriage. Therefore, it is imperative to further strengthen research into in vivo studies, clinical status, pathological mechanisms, and pharmacological interventions for Cd-induced miscarriage. This study systematically presents the current knowledge on animal models and clinical trials investigating Cd exposure-induced miscarriage. The underlying mechanisms involving oxidative stress, inflammation, endocrine disruption, and placental dysfunction caused by Cd-induced miscarriage are also extensively discussed. Additionally, potential drug interventions such as melatonin, vitamin C, and vitamin E are highlighted for their pharmacological role in mitigating adverse pregnancy outcomes induced by Cd. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0147-6513 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0147651324001933; https://doaj.org/toc/0147-6513 |
| DOI: | 10.1016/j.ecoenv.2024.116118 |
| Access URL: | https://doaj.org/article/e97cb49da2174689bf9fc92402413fc1 |
| Accession Number: | edsdoj.97cb49da2174689bf9fc92402413fc1 |
| Database: | Directory of Open Access Journals |
| ISSN: | 01476513 |
|---|---|
| DOI: | 10.1016/j.ecoenv.2024.116118 |
| Published in: | Ecotoxicology and Environmental Safety |
| Language: | English |