Bibliographic Details
| Title: |
Predictive Model for Occurrence of Febrile Neutropenia after Chemotherapy in Patients with Diffuse Large B-Cell Lymphoma: A Multicenter, Retrospective, Observational Study |
| Authors: |
Masaya Morimoto, Yuma Yokoya, Kikuaki Yoshida, Hideki Kosako, Yoshikazu Hori, Toshiki Mushino, Shinobu Tamura, Reiko Ito, Ryosuke Koyamada, Takuya Yamashita, Shinichiro Mori, Nobuyoshi Mori, Sachiko Ohde |
| Source: |
Hematology Reports, Vol 16, Iss 1, Pp 76-88 (2024) |
| Publisher Information: |
MDPI AG, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Diseases of the blood and blood-forming organs |
| Subject Terms: |
febrile neutropenia, chemotherapy, diffuse large B-cell lymphoma, outcomes, multivariate logistic regression model, Diseases of the blood and blood-forming organs, RC633-647.5 |
| More Details: |
Febrile neutropenia (FN) is a major concern in patients undergoing chemotherapy for diffuse large B-cell lymphoma (DLBCL); however, the overall risk of FN is difficult to assess. This study aimed to develop a model for predicting the occurrence of FN in patients with DLBCL. In this multicenter, retrospective, observational analysis, a multivariate logistic regression model was used to analyze the association between FN incidence and pretreatment clinical factors. We included adult inpatients and outpatients (aged ≥ 18 years) diagnosed with DLBCL who were treated with chemotherapy. The study examined 246 patients. Considering FN occurring during the first cycle of chemotherapy as the primary outcome, a predictive model with a total score of 5 points was constructed as follows: 1 point each for a positive hepatitis panel, extranodal involvement, and a high level of soluble interleukin-2 receptor and 2 points for lymphopenia. The area under the receiver operating characteristic curve of this model was 0.844 (95% confidence interval: 0.777–0.911). Our predictive model can assess the risk of FN before patients with DLBCL start chemotherapy, leading to better outcomes. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2038-8330 |
| Relation: |
https://www.mdpi.com/2038-8330/16/1/8; https://doaj.org/toc/2038-8330 |
| DOI: |
10.3390/hematolrep16010008 |
| Access URL: |
https://doaj.org/article/9781e260be084a0e8295e6be2ab270d0 |
| Accession Number: |
edsdoj.9781e260be084a0e8295e6be2ab270d0 |
| Database: |
Directory of Open Access Journals |
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