Bibliographic Details
| Title: |
Antidepressant-like mechanism of honokiol in a rodent model of corticosterone-induced depression |
| Authors: |
Bo Zhang, Yu Li, Miao Liu, Xiao-Hua Duan, Kai-Li Hu, Li-Na Li, Xue Yu, Hong-Sheng Chang |
| Source: |
Journal of Integrative Neuroscience, Vol 19, Iss 3, Pp 459-467 (2020) |
| Publisher Information: |
IMR Press, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
honokiol, antidepressant effect, anti-inflammatory, glucocorticoid receptor, hypothalamus-pituitary-adrenal axis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
Depression is closely linked to hypothalamus-pituitary-adrenal axis hyperactivity. Honokiol, a biphenolic lignan compound obtained from the traditional Chinese medicine Magnolia officinalis, can reduce the activity of the hypothalamus-pituitary-adrenal axis and improve depression-like behavior caused by hypothalamus-pituitary-adrenal axis hyperactivity. The current study investigated the specific mechanism of action of this effect. A depression model was established by repeated injections of corticosterone to study the antidepressant-like effect of honokiol and its potential mechanism. Honokiol prevented the elevated activity of the hypothalamus-pituitary-adrenal axis and the depression-like behavior induced by corticosterone. Treatment with honokiol resulted in greater glucocorticoid receptor mRNA expression, greater glucocorticoid receptor-positive expression, and a greater ratio of glucocorticoid receptor to the mineralocorticoid receptor in the hippocampus. Moreover, honokiol treatment led to lower levels of interleukin-1β in serum and the positive expression of the interleukin-1β receptor in the hippocampus. These results demonstrate that the antidepressant-like mechanism of honokiol, which has effects on inflammatory factors, may act through restoring the typical activity of the hypothalamus-pituitary-adrenal axis by regulating the glucocorticoid receptor-mediated negative feedback mechanism and the balance between glucocorticoid and mineralocorticoid receptors. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1757-448X |
| Relation: |
https://jin.imrpress.com/fileup/1757-448X/PDF/1601432502275-278038978.pdf; https://doaj.org/toc/1757-448X |
| DOI: |
10.31083/j.jin.2020.03.172 |
| Access URL: |
https://doaj.org/article/977dff3c81bb42da9a73357461efddbd |
| Accession Number: |
edsdoj.977dff3c81bb42da9a73357461efddbd |
| Database: |
Directory of Open Access Journals |
