Bibliographic Details
| Title: |
The Effect of Intra-Operative Plethysmography Variability Index-guided Fluid Therapy on Serum Lactate Levels: A Randomized Double-blinded Clinical Trial |
| Authors: |
Omid Azimaraghi, Arash Heroabadi, Alireza Saliminia, Reza Atefyekta, Peyman Saberian, Hojat Dehghanbanadaki, Noushin Khazaei, Ali Movafegh |
| Source: |
Archives of Anesthesia and Critical Care, Vol 6, Iss 2 (2020) |
| Publisher Information: |
Tehran University of Medical Sciences, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Anesthesiology
LCC:Medical emergencies. Critical care. Intensive care. First aid |
| Subject Terms: |
Perioperative care, Fluid therapy, Pleth variability index, Serum lactate, Anesthesiology, RD78.3-87.3, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9 |
| More Details: |
Background: Goal-directed fluid therapy may improve perioperative fluid management. This study aimed to evaluate the effects of Pleth variability index (PVI)-guided fluid therapy on changes in intraoperative serum lactate levels in comparison with liberal fluid therapy. Methods: This study was a randomized double-blinded clinical trial that was conducted in the operating room of a university hospital. Inclusion criteria comprised patients aged 18–60 years and classified as American Society of Anesthesiologists physical status class I and II, who were candidates for elective thyroidectomy. In total, 44 patients meeting the inclusion criteria were enrolled in the study and randomly assigned to two groups: the liberal and PVI groups. In both groups, 5 mL/kg bolus of normal saline was infused prior to the anesthesia induction. In the PVI group, 100 mL bolus of normal saline was administered every 5 min if the PVI remained >13% during the operation. In the liberal group, continuous crystalloid infusion (5–6 mL/kg/h) was administered throughout the surgery. Arterial blood samples were taken, and serum lactate levels were measured following anesthesia induction and just before tracheal extubation. Results: In the PVI group, mean serum lactate decreased at the end of the surgery, with a difference of −0.6 ± 0.13 mmol/L, whereas it increased in the liberal group (0.070 ± 0.3, P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2423-5849 |
| Relation: |
https://aacc.tums.ac.ir/index.php/aacc/article/view/267; https://doaj.org/toc/2423-5849 |
| DOI: |
10.18502/aacc.v6i2.2762 |
| Access URL: |
https://doaj.org/article/977441e29930453d8bbff860a761413b |
| Accession Number: |
edsdoj.977441e29930453d8bbff860a761413b |
| Database: |
Directory of Open Access Journals |
