| Title: |
In silico analysis of LPMO inhibition by ethylene precursor ACCA to combat potato late blight |
| Authors: |
Najla A. Alshaikh, Kahkashan Perveen, Sandip Debnath, Amitava Paul, Ong Ghim Hock, R.Z. Sayyed |
| Source: |
Journal of King Saud University: Science, Vol 36, Iss 10, Pp 103436- (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Science (General) |
| Subject Terms: |
1-amino-cyclopropane-1-carboxylic acid, Molecular docking, Molecular dynamic simulation, Sustainable potato production, Science (General), Q1-390 |
| More Details: |
Potato late blight (PLB), caused by the pathogen Phytophthora infestans, severely threatens potato production worldwide. This study investigates the potential of the ethylene precursor 1-amino-cyclopropane-1-carboxylic acid (ACCA) to inhibit Lytic Polysaccharide Monooxygenases (LPMOs) in P. infestans, a key protein involved in the disease’s pathogenesis. Our findings demonstrate that ACCA significantly enhances the immune response in potato plants against P. infestans, with a binding energy of −8.85 kcal/mol. Integrating ACCA treatment into existing PLB management strategies could offer a novel and sustainable approach to combat this devastating disease. This research provides valuable insights into reducing the global impact of PLB and improving food security through innovative control measures. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1018-3647 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1018364724003483; https://doaj.org/toc/1018-3647 |
| DOI: |
10.1016/j.jksus.2024.103436 |
| Access URL: |
https://doaj.org/article/9759d7e5f298421eba1868ba60085c74 |
| Accession Number: |
edsdoj.9759d7e5f298421eba1868ba60085c74 |
| Database: |
Directory of Open Access Journals |
