Bibliographic Details
| Title: |
The Roles of microRNA miR-185 in Digestive Tract Cancers |
| Authors: |
Esmaeel Babaeenezhad, Fakhraddin Naghibalhossaini, Masoumeh Rajabibazl, Zohreh Jangravi, Forouzan Hadipour Moradi, Mohammad Davood Fattahi, Jörg D. Hoheisel, Mostafa Moradi Sarabi, Soroosh Shahryarhesami |
| Source: |
Non-Coding RNA, Vol 8, Iss 5, p 67 (2022) |
| Publisher Information: |
MDPI AG, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Genetics |
| Subject Terms: |
miR-185, tumor suppressor, oncomiR, oral cancer, gastrointestinal cancer, epigenetics, Genetics, QH426-470 |
| More Details: |
Digestive tract cancers represent a serious public health issue. In recent years, evidence has accumulated that microRNA miR-185 is implicated in the pathogenesis of this group of highly malignant tumors. Its expression variations correlate with clinical features, such as tumor size, lymph node metastasis, tumor node metastatic stage, survival, recurrence and response to adjuvant therapy, and have diagnostic and prognostic potential. In this review, we compile, evaluate and discuss the current knowledge about the roles of miR-185 in digestive tract cancers. Interestingly, miR-185 is apparently involved in regulating both tumor suppressive and oncogenic processes. We look at downstream effects as well as upstream regulation. In addition, we discuss the utility of miR-185 for diagnosis and its potential concerning novel therapeutic approaches. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2311-553X |
| Relation: |
https://www.mdpi.com/2311-553X/8/5/67; https://doaj.org/toc/2311-553X |
| DOI: |
10.3390/ncrna8050067 |
| Access URL: |
https://doaj.org/article/972dbb55c0004dfbab56d0d6f900fb92 |
| Accession Number: |
edsdoj.972dbb55c0004dfbab56d0d6f900fb92 |
| Database: |
Directory of Open Access Journals |
