Academic Journal
Association between MPO-463G > A polymorphism and chronic kidney disease: a meta-analysis
| Title: | Association between MPO-463G > A polymorphism and chronic kidney disease: a meta-analysis |
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| Authors: | Jiaxuan Qin, Jinchun Xing, Wei Li, Kaiyan Zhang, Zhun Wu |
| Source: | Renal Failure, Vol 40, Iss 1, Pp 541-546 (2018) |
| Publisher Information: | Taylor & Francis Group, 2018. |
| Publication Year: | 2018 |
| Collection: | LCC:Diseases of the genitourinary system. Urology |
| Subject Terms: | Myeloperoxidase, single nucleotide polymorphism, rs2333227, chronic kidney disease, meta-analysis, Diseases of the genitourinary system. Urology, RC870-923 |
| More Details: | Background/objective: Previous studies have shown that MPO -463G > A (rs2333227) might be associated with chronic kidney disease (CKD) susceptibility, but sample sizes of those studies are relatively small. Hence, we decided to perform a meta-analysis to evaluate the association. Methods/main results: Two investigators search databases systematically and independently. Odds ratios and 95% confidence intervals were used to pool the effect size. Four articles with 618 cases and 932 controls in total were included in our meta-analysis. Conclusions: MPO -463G > A was not associated with CKD susceptibility in recessive model and homozygote comparison. MPO -463G > A was associated with increased risk of CKD in allelic comparison, heterozygote comparison and dominant model, however, the results lacked stability. Owing to insufficient data, the association between MPO -463G > A and CKD cannot be fully confirmed. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0886-022X 1525-6049 0886022X |
| Relation: | https://doaj.org/toc/0886-022X; https://doaj.org/toc/1525-6049 |
| DOI: | 10.1080/0886022X.2018.1499529 |
| Access URL: | https://doaj.org/article/c96d5e91b4484984a29bba8dcaf51783 |
| Accession Number: | edsdoj.96d5e91b4484984a29bba8dcaf51783 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 0886022X 15256049 |
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| DOI: | 10.1080/0886022X.2018.1499529 |
| Published in: | Renal Failure |
| Language: | English |