The resistance to fluconazole in patients with esophageal candidiasis Resistência ao fluconazol em pacientes com candidíase esofágica
| Title: | The resistance to fluconazole in patients with esophageal candidiasis Resistência ao fluconazol em pacientes com candidíase esofágica |
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| Authors: | Ana Botler Wilheim, Demócrito de Barros Miranda-Filho, Rodrigo Albuquerque Nogueira, Rossana Sette de Melo Rêgo, Kedma de Magalhães Lima, Leila Maria Moreira Beltrão Pereira |
| Source: | Arquivos de Gastroenterologia, Vol 46, Iss 1, Pp 32-37 (2009) |
| Publisher Information: | Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE), 2009. |
| Publication Year: | 2009 |
| Collection: | LCC:Diseases of the digestive system. Gastroenterology |
| Subject Terms: | Candidíase, Esofagiopatias, Fluconazol, Farmacorresistência fúngica, Candidiasis, Esophageal diseases, Fluconazole, Drug resistance, fungal, Diseases of the digestive system. Gastroenterology, RC799-869 |
| More Details: | CONTEXT: Esophageal candidiasis is often observed in patients with risk factors for its development and fluconazole is the therapeutic choice for the treatment of this disease. OBJECTIVES: To determine its frequency, by performing upper digestive endoscopy; to determine Candida species involved in its pathogenesis and verify their distribution according with the predisposing factors and to determine susceptibility to fluconazole in the samples. METHODS: From March 2006 to April 2007, all patients submitted to esophagogastroduodenoscopy at the Digestive Endoscopy Unit in the Oswaldo Cruz University Hospital, Recife, PE, Brazil, were eligible for the study. Samples were collected from patients who presented lesions consistent with esophageal candidiasis in order to identify Candida species and verify their susceptibility to fluconazole. The predisposing factors for the occurrence of esophageal candidiasis were described. RESULTS: Of 2,672 patients referred to upper endoscopy at the Digestive Endoscopy Unit, 40 (1.5%) had endoscopic findings compatible with esophageal candidiasis. The average age was 49.1 years. Twenty one patients (52.5%) were less than 50 years old, of which 82.6% were infected with HIV. Most of them (52.5%) were males and 65.0% were inpatients. Diseases were identified in 90% of the patients and 21 (52.5%) were HIV positive. Concerning endoscopic findings, severe forms of esophagitis were found in 50% of the patients with CD4 count CONTEXTO: A candidíase esofágica é comumente observada em pacientes com fatores de risco para seu desenvolvimento. OBJETIVOS:Determinar a freqüência da candidíase esofágica, por meio da endoscopia digestiva alta; identificar as espécies de Candida envolvidas na patogênese da candidíase esofágica e sua distribuição de acordo com o fator predisponente; determinar a susceptibilidade ao fluconazol nas amostras coletadas. MÉTODOS: De março de 2006 a abril de 2007, os pacientes submetidos a esofagogastroduodenoscopia no Hospital Universitário Oswaldo Cruz, Recife, PE, foram considerados elegíveis para o estudo. Aqueles que apresentaram lesões compatíveis com candidíase esofágica tiveram amostras coletadas para a identificação das espécies de Candida, de sua sensibilidade ao fluconazol e descritos os fatores de risco para a doença. RESULTADOS: Dos 2.672 pacientes encaminhados para endoscopia, 40 (1,5%) apresentaram achados compatíveis com candidíase esofágica. A média de idade foi de 49,1 anos. Vinte e um pacientes (52,5%) tinham menos que 50 anos, dos quais 82,6% eram infectados pelo HIV. A maioria (52,5%) era homens e 65,0% encontravam-se internados. Fatores predisponentes foram identificados em 90% da amostra, sendo que 21 (52,5%) eram HIV positivos. As formas mais graves de esofagite foram encontradas em 50% dos pacientes com CD4 |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0004-2803 1678-4219 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032009000100011; https://doaj.org/toc/0004-2803; https://doaj.org/toc/1678-4219 |
| DOI: | 10.1590/S0004-28032009000100011 |
| Access URL: | https://doaj.org/article/96c6d4cc650142969fb707a759f162de |
| Accession Number: | edsdoj.96c6d4cc650142969fb707a759f162de |
| Database: | Directory of Open Access Journals |
| ISSN: | 00042803 16784219 |
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| DOI: | 10.1590/S0004-28032009000100011 |
| Published in: | Arquivos de Gastroenterologia |
| Language: | English |