Academic Journal
Decreasing trend of blood lipid profile in type 2 diabetes: Not a promising change in HDL-C, a serial cross-sectional study.
| Title: | Decreasing trend of blood lipid profile in type 2 diabetes: Not a promising change in HDL-C, a serial cross-sectional study. |
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| Authors: | Amirhossein Yadegar, Fatemeh Mohammadi, Soghra Rabizadeh, Alipasha Meysamie, Seyed Ali Nabipoorashrafi, Seyed Arsalan Seyedi, Alireza Esteghamati, Manouchehr Nakhjavani |
| Source: | PLoS ONE, Vol 18, Iss 10, p e0293410 (2023) |
| Publisher Information: | Public Library of Science (PLoS), 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Medicine, Science |
| More Details: | BackgroundThe prevalence of dyslipidemia in patients with type 2 diabetes (T2D) has been reported to be relatively high. The current study aimed to investigate the trend of serum lipid levels and the prevalence of dyslipidemia in patients with T2D.MethodsData were extracted from a cohort of patients with T2D who had regular follow-ups every year for three years. TG, TC, LDL-C, HDL-C, and non-HDL-C were analyzed. The atherogenic index of plasma (AIP) was calculated using log (TG/HDL-C).ResultsA total of 747 patients with T2D were included in this study, consisting of 469 (62.8%) women and 278 (37.2%) men. There was a significant downward trend in mean TG, TC, LDL-C, non-HDL-C, and AIP levels. The trend of mean HDL-C levels showed no significant change. The prevalence of high TG, high TC, high LDL-C, and high non-HDL-C significantly decreased from the first to the last visit. There was no significant change in the trend of prevalence of low HDL-C. The prevalence of high AIP significantly decreased in women and showed no significant changes in men.ConclusionsA decreasing trend was observed in the mean levels and prevalence of TG, TC, LDL-C, non-HDL-C, and AIP. HDL-C did not change significantly. The success rate in achieving a complete normal lipid profile during follow-up years was not promising and continues to be challenging. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1932-6203 |
| Relation: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0293410&type=printable; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0293410&type=printable |
| DOI: | 10.1371/journal.pone.0293410 |
| Access URL: | https://doaj.org/article/9693738edce14262b278f92c47226a35 |
| Accession Number: | edsdoj.9693738edce14262b278f92c47226a35 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 19326203 |
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| DOI: | 10.1371/journal.pone.0293410&type=printable |
| Published in: | PLoS ONE |
| Language: | English |