Malignant pleural mesothelioma: an update on diagnosis and treatment options

Bibliographic Details
Title:	Malignant pleural mesothelioma: an update on diagnosis and treatment options
Authors:	Sanjana Kondola, David Manners, Anna K. Nowak
Source:	Therapeutic Advances in Respiratory Disease, Vol 10 (2016)
Publisher Information:	SAGE Publishing, 2016.
Publication Year:	2016
Collection:	LCC:Diseases of the respiratory system
Subject Terms:	Diseases of the respiratory system, RC705-779
More Details:	Malignant pleural mesothelioma (MPM) represents a significant diagnostic and therapeutic challenge and is almost always a fatal disease. Imaging abnormalities are common, but have a limited role in distinguishing mesothelioma from metastatic pleural disease. Similarly, minimally invasive biomarkers have shown promise but also have limitations in the diagnosis of mesothelioma. In experienced centers, cytology and immunohistochemistry are now sufficient to diagnose the epithelioid subtype of mesothelioma, which can reduce the need for more invasive diagnostic investigations. Prognosis of MPM is modestly impacted by oncological treatments. Chemotherapy with cisplatin and pemetrexed is considered the standard of care, though the addition of bevacizumab to the platinum doublet may be the new standard of care. New targeted therapies have demonstrated some promise and are being addressed in clinical trials. This review focuses on the current data on the diagnostic and therapeutic issues of MPM.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1753-4658 1753-4666 17534658
Relation:	https://doaj.org/toc/1753-4658; https://doaj.org/toc/1753-4666
DOI:	10.1177/1753465816628800
Access URL:	https://doaj.org/article/c9633049db3943ca8d8c1e5b5ee2c11f
Accession Number:	edsdoj.9633049db3943ca8d8c1e5b5ee2c11f
Database:	Directory of Open Access Journals

More Details
ISSN:	17534658 17534666
DOI:	10.1177/1753465816628800
Published in:	Therapeutic Advances in Respiratory Disease
Language:	English