Academic Journal
Neurite Outgrowth-Promoting Compounds from the Petals of Paeonia lactiflora in PC12 Cells
| Title: | Neurite Outgrowth-Promoting Compounds from the Petals of Paeonia lactiflora in PC12 Cells |
|---|---|
| Authors: | Takeru Koga, Hideyuki Ito, Yuji Iwaoka, Toshiro Noshita, Akihiro Tai |
| Source: | Molecules, Vol 27, Iss 22, p 7670 (2022) |
| Publisher Information: | MDPI AG, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Organic chemistry |
| Subject Terms: | Paeonia lactiflora, PC12 cells, NGF, isorhamnetin-3-O-glucoside, astragalin, neurite outgrowth-promoting activity, Organic chemistry, QD241-441 |
| More Details: | Isorhamnetin-3-O-glucoside and astragalin, flavonol glucosides, were isolated from the petals of Paeonia lactiflora as neurite outgrowth-promoting compounds. Isoquercitrin, formed by demethylating the B ring of isorhamnetin-3-O-glucoside or by adding a hydroxyl group to the B ring of astragalin, was evaluated for neurite outgrowth-promoting activity and was compared with the activities of isorhamnetin-3-O-glucoside and astragalin. The activities of isorhamnetin, kaempferol, and quercetin, aglycones corresponding to isorhamnetin-3-O-glucoside, astragalin, and isoquercitrin, respectively, were also evaluated. Isorhamnetin-3-O-glucoside and astragalin showed much stronger neurite outgrowth-promoting activities than the activities of the other tested flavonoids. They exhibited relatively weak anti-oxidant activities and moderate AChE inhibitory activities compared to the activities of the other tested flavonoids. Isorhamnetin-3-O-glucoside and astragalin promoted morphological neurite outgrowth and the expression of neurofilaments induced by NGF in PC12 cells. Isorhamnetin-3-O-glucoside and astragalin might be candidate compounds as neural differentiation agents in peripheral nerves and functional food ingredients preventing cognitive decline. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1420-3049 |
| Relation: | https://www.mdpi.com/1420-3049/27/22/7670; https://doaj.org/toc/1420-3049 |
| DOI: | 10.3390/molecules27227670 |
| Access URL: | https://doaj.org/article/9625543d1d64442f9ed53e0a6227e0ee |
| Accession Number: | edsdoj.9625543d1d64442f9ed53e0a6227e0ee |
| Database: | Directory of Open Access Journals |
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