| Title: |
Skewed Cytokine Responses Rather Than the Magnitude of the Cytokine Storm May Drive Cardiac Dysfunction in Multisystem Inflammatory Syndrome in Children |
| Authors: |
Joyce C. Chang, Daisuke Matsubara, Ryan W. Morgan, Caroline Diorio, Sumekala Nadaraj, David T. Teachey, Hamid Bassiri, Edward M. Behrens, Anirban Banerjee |
| Source: |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 16 (2021) |
| Publisher Information: |
Wiley, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
COVID‐19, cytokine storm, echocardiography, multisystem inflammatory syndrome in children, myocardial deformation, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
Background Cardiac dysfunction is a prominent feature of multisystem inflammatory syndrome in children (MIS‐C), yet the etiology is poorly understood. We determined whether dysfunction is global or regional, and whether it is associated with the cytokine milieu, microangiopathy, or severity of shock. Methods and Results We analyzed echocardiographic parameters of myocardial deformation and compared global and segmental left ventricular strain between 43 cases with MIS‐C ≤18 years old and 40 controls. Primary outcomes included left ventricular global longitudinal strain, right ventricular free wall strain), and left atrial strain. We evaluated relationships between strain and profiles of 10 proinflammatory cytokines, microangiopathic features (soluble C5b9), and vasoactive‐inotropic requirements. Compared with controls, cases with MIS‐C had significant impairments in all parameters of systolic and diastolic function. 65% of cases with MIS‐C had abnormal left ventricular function (|global longitudinal strain| |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2047-9980 |
| Relation: |
https://doaj.org/toc/2047-9980 |
| DOI: |
10.1161/JAHA.121.021428 |
| Access URL: |
https://doaj.org/article/a95b054e755c408ca84d32a9616c7ee8 |
| Accession Number: |
edsdoj.95b054e755c408ca84d32a9616c7ee8 |
| Database: |
Directory of Open Access Journals |
