Donated chemical probes for open science
| Title: | Donated chemical probes for open science |
|---|---|
| Authors: | Susanne Müller, Suzanne Ackloo, Cheryl H Arrowsmith, Marcus Bauser, Jeremy L Baryza, Julian Blagg, Jark Böttcher, Chas Bountra, Peter J Brown, Mark E Bunnage, Adrian J Carter, David Damerell, Volker Dötsch, David H Drewry, Aled M Edwards, James Edwards, Jon M Elkins, Christian Fischer, Stephen V Frye, Andreas Gollner, Charles E Grimshaw, Adriaan IJzerman, Thomas Hanke, Ingo V Hartung, Steve Hitchcock, Trevor Howe, Terry V Hughes, Stefan Laufer, Volkhart MJ Li, Spiros Liras, Brian D Marsden, Hisanori Matsui, John Mathias, Ronan C O'Hagan, Dafydd R Owen, Vineet Pande, Daniel Rauh, Saul H Rosenberg, Bryan L Roth, Natalie S Schneider, Cora Scholten, Kumar Singh Saikatendu, Anton Simeonov, Masayuki Takizawa, Chris Tse, Paul R Thompson, Daniel K Treiber, Amélia YI Viana, Carrow I Wells, Timothy M Willson, William J Zuercher, Stefan Knapp, Anke Mueller-Fahrnow |
| Source: | eLife, Vol 7 (2018) |
| Publisher Information: | eLife Sciences Publications Ltd, 2018. |
| Publication Year: | 2018 |
| Collection: | LCC:Medicine LCC:Science LCC:Biology (General) |
| Subject Terms: | Chemical probes, Target validation, Open Science, Medicine, Science, Biology (General), QH301-705.5 |
| More Details: | Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose. Several pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, and Takeda) have therefore entered into a pre-competitive collaboration to make available a large number of innovative high-quality probes, including all probe-associated data, control compounds and recommendations on use (https://openscienceprobes.sgc-frankfurt.de/). Here we describe the chemical tools and target-related knowledge that have been made available, and encourage others to join the project. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2050-084X 31440495 |
| Relation: | https://elifesciences.org/articles/34311; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.34311 |
| Access URL: | https://doaj.org/article/959198e7fd31440495c0d4c7cf3c5c06 |
| Accession Number: | edsdoj.959198e7fd31440495c0d4c7cf3c5c06 |
| Database: | Directory of Open Access Journals |
| ISSN: | 2050084X 31440495 |
|---|---|
| DOI: | 10.7554/eLife.34311 |
| Published in: | eLife |
| Language: | English |